载脂蛋白A1和载脂蛋白B100在冠脉病变进展中的作用

发布时间：2018-06-15 06:19

本文选题：载脂蛋白A + 载脂蛋白B　；参考：《中山大学学报(医学科学版)》2017年03期

【摘要】：【目的】通过回顾性资料,分析载脂蛋白(APO)A1、B100对冠状动脉病变进展的影响及预测作用。【方法】入选2010年6月至2015年10月于中山大学附属第三医院行冠状动脉造影或冠脉CTA检查,并在间隔≥6个月后复查冠脉情况的患者(245例),分为冠脉病变非进展组(114例)、进展组(131例)。比较两组间临床资料及生化指标差异,并通过回归分析,了解APOA1、APOB100与冠脉病变进展的关系。【结果】两组比较,冠脉病变非进展组基线APOA1水平(1.33±0.29 vs 1.24±0.25,P=0.015)、APOA1/AOPB100(1.56±0.65 va 1.38±0.44,P=0.014)更高;两组基线AOPB100水平(0.96±0.37 vs 0.97±0.31,P=0.87)无差异。两组随访APOA1水平均较基线水平均升高,冠脉病变进展组APOA1水平变化有统计学意义(1.24±0.25 vs 1.31±0.28,P=0.006)。通过单因素回归分析,基线APOA1、APOA1/APOB100水平与冠脉病变进展负相关;通过多因素回归分析,APOA1(OR=0.245,P=0.005)与冠脉病变进展负相关。【结论】APOA1水平与冠脉病变负相关,可能具有延缓冠脉病变进展作用,且可能有利于预测冠脉病变进展风险。
[Abstract]:[objective] to analyze the effect of apolipoprotein Apo-A1B100 on the progression of coronary artery disease and its predictive effect. [methods] Coronary angiography or coronary CTA examination was performed in the third affiliated Hospital of Sun Yat-sen University from June 2010 to October 2015. 245 patients with coronary artery disease were divided into two groups: the non-progressive group (114 cases) and the advanced group (131 cases). To compare the clinical data and biochemical indexes between the two groups, and to understand the relationship between APOA1 / APOB100 and the progression of coronary artery disease by regression analysis. [results] the baseline APOA1 level was 1.33 卤0.29 vs 1.24 卤0.25g / L APOA1 / AOPB1001.56 卤0.65va 1.38 卤0.44P0. 014 in the two groups. The baseline AOPB100 level in the two groups was 0.96 卤0.37 vs 0.97 卤0.31, and there was no difference between the two groups. The levels of APOA1 in both groups were higher than the baseline level, and the changes of APOA1 level in the coronary artery disease progression group were significantly higher than those in the baseline group (1.24 卤0.25 vs 1.31 卤0.28 P0. 006). By univariate regression analysis, the baseline APOA1 / APOB100 level was negatively correlated with the progression of coronary artery disease, and the level of APOA1 / APOB100 was negatively correlated with the progression of coronary artery disease by multivariate regression analysis. [conclusion] APOA1 level is negatively correlated with coronary artery disease. It may delay the progression of coronary artery disease, and may be helpful to predict the risk of coronary artery disease progression.
【作者单位】：中山大学附属第三医院心血管内科;中山大学附属第一医院心血管内科;
【基金】：广东省科技计划项目(2009B030801146)
【分类号】：R541.4

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