北京社区人群血压与颈动脉内中膜厚度的相关性探讨

发布时间：2018-06-16 21:50

  本文选题：颈动脉内中膜厚度 + 收缩压　； 参考：《环境与健康杂志》2017年06期

【摘要】：目的探讨颈动脉内中膜厚度增厚与否对血压与颈动脉内中膜厚度相关性的影响。方法研究人群来自北京大学第一医院心内科于2011年12月至2012年4月在北京市石景山区横断面调查的动脉粥样硬化研究队列。纳入标准为问卷调查资料完整并完成颈动脉超声图像的采集且未应用过任何降压药物,研究人群(n=2 569)以最大颈动脉内中膜厚度0.9 mm为分界点分为颈动脉内中膜厚度增厚组(n=1 597)及非增厚组(n=972),分析血压与颈动脉内中膜厚度的关系。结果多重线性回归分析显示,在调整了性别、年龄、BMI、目前吸烟饮酒状况、血肌酐、空腹血糖、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯、降糖降脂药物使用、心血管疾病患病情况等因素后,总体人群各项血压指标(收缩压、舒张压、脉压及平均动脉压)均与颈动脉内中膜厚度平均值呈显著正相关(收缩压:β=0.009,P0.000 1;舒张压:β=0.002,P0.000 1;脉压:β=0.007,P0.000 1;平均动脉压:β=0.009,P0.000 1);在颈动脉内中膜厚度≥0.9 mm组各项血压指标依然与颈动脉内中膜厚度平均值呈显著正相关(收缩压:β=0.006,P=0.000 1;舒张压:β=0.001,P=0.000 1;脉压:β=0.005,P0.0001;平均动脉压:β=0.005,P=0.023 8),而非增厚组中各项血压指标与颈动脉内中膜厚度平均值均无明显相关。结论本研究发现在颈动脉内中膜厚度增厚的人群中血压指标与颈动脉内中膜厚度显著相关,非增厚人群中无显著相关。提示血管壁增厚影响血压的作用机制在二者相关性机制方面可能占据更重要的地位。
[Abstract]:Objective to investigate the effect of carotid intima-media thickness (IMT) on blood pressure and carotid intima-media thickness (IMT). Methods A cross-sectional investigation of atherosclerosis was conducted in Shijingshan District of Beijing from December 2011 to April 2012 in Department of Cardiology, first Hospital of Peking University. The inclusion criteria were complete questionnaire data, complete carotid ultrasound image acquisition and no antihypertensive drugs were used. The maximum carotid intima media thickness (0.9 mm) was divided into two groups: carotid intima-media thickness (IMT) group (n = 1597) and non-thickening group (n = 997 2). The relationship between blood pressure and carotid intima media thickness (IMT) was analyzed. Results multiple linear regression analysis showed that after adjusting for sex, age and BMIs, current smoking and drinking status, serum creatinine, fasting blood glucose, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride, hypoglycemic and lipid-lowering drug use, After the prevalence of cardiovascular disease and other factors, the whole population blood pressure indicators (systolic blood pressure, diastolic blood pressure, Both pulse pressure and mean arterial pressure were positively correlated with the mean IMT of carotid artery (systolic blood pressure: 尾 0.009 P0.000 1; diastolic blood pressure: 尾 0.002 + P0.000 1; pulse pressure: 尾 0.007 P0.000 1; mean arterial pressure: 尾 0.009 P0.000 1; in the group of carotid intima-media thickness 鈮，

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