尼可地尔对心脏X综合征的疗效及对血管内皮功能的影响

发布时间：2018-06-17 18:45

本文选题：微血管性心绞痛 + 尼可地尔　；参考：《中国循环杂志》2017年07期

【摘要】：目的:观察尼可地尔治疗心脏X综合征的临床疗效及其对血管内皮功能的影响。方法:对140例心脏X综合征患者按照随机数字表随机分组,对照组70例给予常规抗心绞痛药物治疗,尼可地尔组70例在常规治疗基础上加用尼可地尔口服。患者均行静息心肌核素扫描(ECT)和平板运动试验检查,检测治疗前后(随访3个月)血浆内皮素(ET-1)、血清高敏C反应蛋白(hs-CRP)及一氧化氮(NO)水平变化。结果:尼可地尔组和对照组患者治疗后心绞痛发作频率和ECT阳性率均较治疗前降低(P0.05)。尼可地尔组治疗后心电图平板运动试验可疑阳性率及阳性率较治疗前明显下降,差异有统计学意义(P0.05);治疗后尼可地尔组较对照组心电图平板运动试验可疑阳性率及阳性率明显降低,差异均有统计学意义(P均0.05)。血清学指标结果显示:治疗后对照组、尼可地尔组的ET-1、hs-CRP水平较治疗前均下降,而NO水平均上升,差异均有统计学意义(P均0.05);治疗后两组间比较ET-1、hs-CRP和NO水平差异均有统计学意义(P均0.05)。结论:尼可地尔通过抑制炎症因子、改善血管内皮功能机制来改善微血管性心绞痛症状,提高运动耐量,且疗效显著。
[Abstract]:Objective: to observe the clinical effect of nicorandil in the treatment of cardiac X syndrome and its effect on vascular endothelial function. Methods: 140 patients with cardiac X syndrome were randomly divided into control group (n = 70) and nicorandil group (n = 70). Resting myocardial radionuclide scanning (ECT) and treadmill exercise test were performed to detect the changes of plasma endothelin (et 1), serum Gao Min C reactive protein (Gao Min C reactive protein) and nitric oxide (no) before and after treatment (follow-up for 3 months). Results: after treatment, the frequency of angina pectoris attack and the positive rate of ECT in nicordil group and control group were lower than those before treatment (P 0.05). The suspicious positive rate and positive rate of electrocardiogram treadmill exercise test in nicorandil group were significantly lower than those before treatment. After treatment, the suspected positive rate and positive rate of ECG treadmill exercise test in nicordil group were significantly lower than those in control group (P < 0.05). The results of serological indexes showed that after treatment, the ET-1hs-CRP levels in the nicorandil group were lower than those before treatment, while no levels were increased. There were significant differences in ET-1hs-CRP and no levels between the two groups after treatment (P < 0.05). Conclusion: nicorandil can improve the symptoms of microvascular angina pectoris and exercise tolerance by inhibiting inflammatory factors and improving vascular endothelial function.
【作者单位】：陕西中医药大学第二附属医院心血管内科;延安大学咸阳医院内分泌科;
【分类号】：R541.4

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