新疆维吾尔族、蒙古族原发性高血压患者血清亲环素A的表达及意义研究

发布时间：2018-06-17 20:31

本文选题：高血压 + 亲环素A　；参考：《石河子大学》2015年硕士论文

【摘要】：目的:比较新疆维吾尔族和蒙古族原发性高血压(EH)患者与血压正常组(NT)血清亲环素A(Cy PA)水平,探讨其与血压、肥胖、血脂、血糖等指标的关系;探讨血清亲环素A在两种不同民族的差异性。方法:(1)以新疆157名维吾尔族人(EH组81人,对照组76人)及160名蒙古族人(EH组83人,对照组77人)为研究对象,检测血压、腰围(WC)、腰臀比(WHR)、体质量指数(BMI)、血脂、血糖(FPG)等指标,并采集血样。(2)用酶联免疫吸附试验(ELISA)测定血清亲环素A水平。(3)采用SPSS17.0统计软件进行统计学处理,两组间比较采用两独立样本t检验,采用Pearson相关分析及多元线性逐步回归分析法分析血清亲环素A与其他指标的相关性,以P0.05为差异有统计学意义。结果:(1)维吾尔族EH组与NT组一般资料比较:维吾尔族EH组中的SBP、DBP、WC、WHR、FPG均高于维吾尔族NT组,差异有统计学意义(P0.05);维吾尔族EH中的HDL-C低于维吾尔族NT组,差异有统计学意义(P0.05);维吾尔EH中的BMI、TC、TG、LDL-C平均水平均高于维吾尔族NT组,差异无统计学意义(P0.05)。(2)蒙古族EH组与NT组一般资料比较:蒙古族EH中的SBP、DBP、BMI、WHR、TC、TG、LDL-C均高于蒙古族NT组,差异有统计学意义(P0.05);蒙古族EH中的HDL-C低于蒙古族NT组,差异有统计学意义(P0.05);蒙古族EH中的WC、FPG均高于蒙古族NT组,差异无统计学意义(P0.05)。(3)蒙古族EH组与维吾尔族EH组一般资料比较:蒙古族EH组中的S BP、BMI、TC、TG、HDL-C、LDL-C均高于维吾尔族EH组,差异有统计学意义(P0.05);蒙古族EH组中DBP高于维吾尔族EH组,差异无统计学意义(P0.05)。蒙古族EH组中的WC、WHR低于维吾尔族EH组,差异有统计学意义(P0.05)。蒙古族EH组中的FPG低于维吾尔族EH组,差异无统计学意义(P0.05)。(4)蒙古族NT组与维吾尔族NT组一般资料比较:蒙古族NT组中的HDL-C、LDL-C、FPG均高于维吾尔族NT组,差异有统计学意义(P0.05);蒙古族NT中的SBP、DBP、BMI、TC、TG平均水平高于维吾尔NT,差异无统计学意义(P0.05);蒙古族NT组中的WC、WHR低于维吾尔NT组,差异无统计学意义(P0.05)。(5)维吾尔族、蒙古族EH组与各自NT组血清亲环素A水平比较:维吾尔族、蒙古族EH组血清亲环素A水平均高于各自对应NT组,有统计学意义(P0.05);蒙古族EH组血清亲环素A水平高于维吾尔族EH组,有统计学差异(P0.05);蒙古族NT组血清亲环素A水平高于维吾尔族NT组,有统计学差异(P0.05)。(6)Pearson相关分析显示:在维吾尔族EH组中,血清亲环素A水平与SBP、DBP、WHR呈显著正相关(P0.05);在维吾尔族NT组中,血清亲环素A水平与BMI、WHR呈显著正相关(P0.05);在蒙古族EH中,血清亲环素A水平与SBP、DBP、BMI、WC、WHR、TC、LDL-C呈显著正相关(P0.05);在蒙古族NT组中,血清亲环素A水平与BMI呈明显正相关(P0.05);多元线性逐步回归分析显示:血压是影响维吾尔、蒙古族EH血清亲环素A水平的因素。结论:(1)新疆蒙古族、维吾尔族原发性高血压患者血清亲环素A水平均明显高于其血压正常组,血清亲环素A水平与血压有关,提示血清亲环素A参与了高血压的发生和发展。(2)血清亲环素A水平在新疆蒙古族原发性高血压患者明显高于维吾尔族高血压患者,提示血清亲环素A在新疆维吾尔族、蒙古族高血压患者中的水平分布存在民族差异性。
[Abstract]:Objective: To compare the levels of serum proactive cyclophilin A (Cy PA) in Xinjiang Uygur and Mongolian hypertension (EH) patients and normal blood pressure group (NT), to explore the relationship with blood pressure, obesity, blood lipid and blood glucose, and to explore the difference of serum Pro cyclin A in two different nationalities. Methods: (1) 157 Uygur people in Xinjiang (group EH, 81, control 7) 6 people and 160 Mongolian people (group EH 83, control group 77) were studied. Blood pressure, waist circumference (WC), waist to hip ratio (WHR), body mass index (BMI), blood lipid, blood glucose (FPG) and other indexes, and blood samples were collected. (2) enzyme linked immunosorbent assay (ELISA) was used to determine serum cyclophilin A level. (3) statistical treatment with SPSS17.0 statistical software, two groups between two groups The correlation of serum Pro cyclin A and other indexes was analyzed by Pearson correlation analysis and multiple linear stepwise regression analysis with two independent sample t tests. The results were as follows: (1) the general data of Uygur EH group and NT group: SBP, DBP, WC, WHR in the EH group of the Uygur nationality, which were higher than those of Uygur. T group, the difference was statistically significant (P0.05); HDL-C in Uygur EH was lower than the Uygur group NT group, the difference was statistically significant (P0.05); the average level of BMI, TC, TG, LDL-C in Uygur EH was higher than that of the Uygur NT group, the difference was not statistically significant. (2) the Mongolian minority group was compared with the general data of the group. C, TG, LDL-C were higher than the Mongolian group NT group, the difference was statistically significant (P0.05); the HDL-C in the Mongolian EH was lower than that of the Mongolian NT group, and the difference was statistically significant (P0.05); the WC in the Mongolian EH was higher than that of the Mongolian group. (3) the general data of the Mongolian group and the Uygur group were compared. P, BMI, TC, TG, HDL-C, LDL-C were higher than the Uygur EH group, the difference was statistically significant (P0.05), and the DBP of the Mongolian EH group was higher than the Uygur EH group, the difference was less than that of the Uygur group. Study significance (P0.05). (4) the general data of the Mongolian NT group and the Uygur NT group: the HDL-C, LDL-C and FPG in the Mongolian group NT group are higher than the Uygur NT group, and the difference is statistically significant (P0.05); the average level of the Mongolian NT is higher than that of the Uygur group, and the difference is not statistically significant. Uygur NT group, the difference was not statistically significant (P0.05). (5) Uygur, Mongolian EH group and their respective NT group serum cyclophilin A level: Uygur, Mongolian EH group serum cyclophilin A level is higher than the corresponding NT group, there is statistical significance (P0.05); Mongolian EH group serum cyclophilin A level is higher than the Uygur EH group, there is a statistical difference. The level of serum Pro cyclin A in Mongolian NT group was higher than that of Uygur group NT group (P0.05). (6) Pearson correlation analysis showed that in Uygur EH group, serum cyclin A level was significantly positively correlated with SBP, DBP, WHR (P0.05); in Uygur minority group, serum cyclophilin level was significantly positive correlation. In Mongolian EH, serum levels of cyclophilin A were significantly positively correlated with SBP, DBP, BMI, WC, WHR, TC, and LDL-C (P0.05). In the Mongolian NT group, the level of serum cyclophilin A levels was positively correlated. The multivariate linear stepwise regression analysis showed that blood pressure was the factor affecting the level of serum cyclophilin in the Mongolian nationality. (1) Xinjiang Mongolian, The level of serum Pro cyclin A in Uygur patients with essential hypertension was significantly higher than that of normal blood pressure group. Serum cyclin A level was related to blood pressure, suggesting that serum cyclophilin A was involved in the occurrence and development of hypertension. (2) serum cyclin A level in Xinjiang Mongolian patients with primary hyperblood pressure was significantly higher than Uygur hypertensive patients, The level of serum cyclophilin A in Xinjiang Uygur and Mongolian hypertensive patients is different.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.11

【参考文献】