血府逐瘀汤联合西药治疗老年难治性高血压的临床研究

发布时间：2018-06-19 06:02

本文选题：血府逐瘀汤 + 西药　；参考：《中国临床药理学杂志》2017年12期

【摘要】：目的观察血府逐瘀汤联合西药治疗老年难治性高血压的临床疗效。方法将120例难治性高血压患者随机将分为对照组60例和试验组60例。对照组患者给予普萘洛尔片,每次5~10 mg,每日3~4次,口服;卡托普利片,每次12.5 mg,每日2~3次,口服;吲达帕胺片,每次2.5 mg,每日1次,口服。试验组在对照组的基础上增加中药汤剂血府逐瘀汤100 mL,每天1剂,早晚各服用半剂,口服。2组均治疗90 d。观察2组患者的临床症状和血压变化情况,评价2组患者的临床疗效。结果试验组总有效率为95.00%(57/60例),对照组为78.33%(47/60例),差异有统计学意义(P0.05)。治疗后,对照组和试验组患者收缩压分别为(130.09±9.95),(113.08±15.24)mmHg,对照组和试验组患者舒张压分别为(84.40±9.05),(81.02±6.56)mmHg,差异有统计学意义(P0.05)。试验组无药物不良反应发生,对照组发生头晕1例,2组患者的不良反应发生率差异无统计学意义(P0.05)。结论血府逐瘀汤联合西药可有效治疗老年难治性高血压。
[Abstract]:Objective to observe the clinical effect of Xuefu Zhuyu decoction combined with western medicine on refractory hypertension in the elderly. Methods 120 patients with refractory hypertension were randomly divided into control group (n = 60) and trial group (n = 60). The patients in the control group were given propranolol tablets (5 mg / d, 3 mg / d), captopril tablets (12.5 mg / d, 23 times a day) and indapamide tablets (2.5 mg / d, 1 time per day). The experimental group added 100 mL of traditional Chinese medicine decoction Xuefu Zhuyu decoction on the basis of the control group, one dose per day, half a dose in the morning and evening, all treated for 90 days in the oral .2 group. The clinical symptoms and blood pressure of the two groups were observed and the clinical efficacy was evaluated. Results the total effective rate of the trial group was 95.00% and that of the control group was 78.33%. The total effective rate of the control group was 78.33%. The difference was statistically significant (P 0.05). After treatment, systolic blood pressure (SBP) in the control group and the test group was 113.08 卤15.24 mm Hg, respectively, and the diastolic pressure in the control group and the experimental group was 81.02 卤6.56 mm Hg, respectively. The difference was statistically significant (P 0.05). There was no adverse drug reaction in the trial group, but there was no significant difference in the incidence of adverse drug reactions in the control group (1 case with dizziness) (P 0.05). Conclusion Xuefu Zhuyu decoction combined with western medicine can effectively treat elderly refractory hypertension.
【作者单位】：宁波市第一医院中西医结合科;
【基金】：浙江省自然科学基金资助项目(LY14H090003)
【分类号】：R544.1

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