microRNA在动脉硬化闭塞症中调控血管平滑肌的作用机制

发布时间：2018-06-19 23:50

本文选题：动脉硬化闭塞症 + microRNA　；参考：《中国动脉硬化杂志》2017年02期

【摘要】：动脉硬化闭塞症已成为周围血管疾病的首要病症,严重危害人们身心健康,早期诊断及治疗尤为迫切和必要。近年来,随着非蛋白机制和转录后机制研究的逐渐清晰,部分研究聚焦于探索microRNA与动脉硬化闭塞症之间的关系。文章依据microRNA在动脉硬化闭塞症细胞模型、动物模型和患者水平中调控血管平滑肌细胞的增殖、迁移、分化、表型转换和凋亡等方面来进行学习和研究。microRNA的研究从基因调控方面更好地解释了动脉硬化闭塞症的发生与发展,但由于其中复杂的调控机制以及缺乏药代学和药效学研究数据、作用靶基因众多等因素,其临床应用仍然受到制约。展望未来,应用microRNA治疗药剂治疗血管疾病特别是下肢动脉硬化闭塞症将有效减少其带来的损害。
[Abstract]:Arteriosclerotic obliteration has become the primary disease of peripheral vascular diseases, which seriously endangers people's physical and mental health. Early diagnosis and treatment are particularly urgent and necessary. In recent years, as the studies of non-protein and post-transcriptional mechanisms have become clear, some studies have focused on exploring the relationship between microRNA and arteriosclerosis obliterans. In this paper, microRNA was used to regulate the proliferation, migration and differentiation of vascular smooth muscle cells in arteriosclerotic occlusive disease cell model, animal model and patient level. Phenotypic transformation and apoptosis. The study of microRNA can better explain the occurrence and development of arteriosclerosis obliterans in terms of gene regulation, but due to the complex regulatory mechanisms and the lack of pharmacokinetic and pharmacodynamic research data, Its clinical application is still restricted by many factors such as target genes. In the future, the application of microRNA in the treatment of vascular diseases, especially arteriosclerosis obliterans of lower extremities, will effectively reduce the damage caused by microRNA.
【作者单位】：西南医科大学附属第一医院血管甲状腺外科;
【基金】：四川省教育厅自然科学基金项目(14TD0018) 四川省卫生计生委科研基金项目(140035)
【分类号】：R543.5

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