门控心肌灌注显像评价心可舒片治疗冠状动脉慢血流55例临床研究

发布时间：2018-06-19 23:54

本文选题：冠状动脉慢血流 + 心可舒片　；参考：《中医杂志》2017年24期

【摘要】：目的评价心可舒片治疗冠状动脉慢血流(CSF)的临床疗效。方法将110例CSF患者随机分为心可舒组和对照组各55例。对照组给予抗心绞痛常规治疗,心可舒组在常规治疗的基础上加用心可舒片,每次1.24 g,每日3次。两组均治疗6个月。治疗前后采用门控心肌灌注显像技术评价心肌受损情况,并采用门控分析软件计算左心室功能参数,测定血浆同型半胱氨酸(Hcy)、肿瘤坏死因子α(TNF-α)、一氧化氮(NO)及内皮素1(ET-1)水平;治疗后判定临床疗效。出院后随访1年,观察不良事件的发生情况。结果心可舒组临床疗效有效率为72.73%,明显高于对照组的50.91%(χ2=5.546,P=0.019)。心可舒组55例患者共发现151个亚段异常,治疗后改善120个,对照组55例患者共发现148个亚段异常,治疗后改善79个,心可舒组受损心肌改善情况明显优于对照组(χ2=4.626,P=0.031)。治疗后心可舒组患者高峰充盈率(PFR)、高峰充盈时间(TPFR)、前l/3充盈时间平均充盈率(MFR/3)及血浆Hcy、TNF-α、ET-1、NO均较对照组改善明显(P0.05)。两组随访期内均未发生心血管事件。结论心可舒片治疗CSF疗效确切,可改善CSF患者心肌灌注异常和左心室的舒张功能,降低炎性反应。
[Abstract]:Objective to evaluate the clinical efficacy of Xin Ke Shu tablets (CSF) in the treatment of slow coronary artery flow (CSF). Methods the patients were randomly divided into 110 CSF patients and 55 patients in the control group. The control group was given conventional treatment for angina pectoris. The heart recomfort group was treated with the routine treatment, 1.24 g each time, 3 times a day. The two groups were treated for 6 months. The treatment was treated before and after treatment. The myocardial damage was evaluated by gated myocardial perfusion imaging, and the function parameters of left ventricle were calculated by gating analysis software. Plasma homocysteine (Hcy), tumor necrosis factor alpha (TNF- alpha), nitric oxide (NO) and endothelin 1 (ET-1) were measured. The clinical efficacy was determined after treatment. After 1 years of follow-up, the occurrence of adverse events was observed. Results the effective rate of clinical efficacy of XXXXX group was 72.73%, significantly higher than 50.91% in control group (x 2=5.546, P=0.019). 151 subsegments were found in 55 patients in XXXXXX group and 120 were improved after treatment. 55 patients in the control group found 148 subsegments, and 79 were improved after treatment. The improvement of damaged myocardium in XXXXXX group was obviously better than that in the control group. Group (x 2=4.626, P=0.031). After treatment, the peak filling rate (PFR), peak filling time (TPFR), the average filling rate of pre l/3 filling time (MFR/3) and plasma Hcy, TNF- a, ET-1, NO were all better than the control group (P0.05). The two groups did not have cardiovascular events during the follow-up period. Abnormal myocardial perfusion and left ventricular diastolic function in patients with decreased inflammatory response.
【作者单位】：石家庄市第四医院;河北医科大学第三医院;
【分类号】：R541.4

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