生长分化因子-15表达水平与心肌梗死致心力衰竭程度的相关性

发布时间：2018-06-20 13:59

  本文选题：生长分化因子- + 心肌梗死　； 参考：《中国老年学杂志》2017年20期

【摘要】：目的探讨心肌梗死致心力衰竭程度与生长分化因子(GDF)-15表达水平的相关性。方法 50例心肌梗死致心力衰竭患者为研究组,同期选取入院体检的50例健康者为对照组。检测两组静脉血、血清中GDF-15表达水平,分析患者心力衰竭程度与GDF-15表达水平的相关性。结果研究组血清中GDF-15表达水平显著高于对照组(P0.05)。研究组血清中GDF-15表达水平伴随心力衰竭程度的严重而上升(P0.05)。研究组心功能Ⅰ级8例(16.0%),心力衰竭Ⅰ度21例(42.0%),Ⅱ度15例(30.0%),Ⅲ度6例(12.0%)。Spearman相关分析发现,心肌梗死患者血浆GDF-15表达水平与心肌梗死致心力衰竭程度呈正相关性(r=0.027,P0.05),急性患者的心力衰竭程度越严重,其血浆GDF-15的表达水平越高。结论在心肌梗死致心衰患者的临床诊断中,检测血清中GDF-15表达水平对判断心衰程度具有重要价值。
[Abstract]:Objective to investigate the relationship between the degree of heart failure induced by myocardial infarction and the expression of growth differentiation factor (GDF- 15). Methods 50 patients with heart failure caused by myocardial infarction were selected as study group and 50 healthy persons as control group. The expression of GDF-15 in venous blood and serum was detected and the correlation between the degree of heart failure and the expression of GDF-15 was analyzed. Results the expression of GDF-15 in serum of the study group was significantly higher than that of the control group (P 0.05). The expression of GDF-15 in serum of the study group increased with the severity of heart failure (P 0.05). In the study group, there were 8 patients with grade 鈪，

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