急性心肌梗死患者红细胞分布宽度与平均血小板体积的回归分析

发布时间：2018-06-21 06:55

本文选题：不稳定型心绞痛 + 急性心肌梗死　；参考：《南方医科大学学报》2017年08期

【摘要】：目的研究急性心肌梗死患者红细胞分布宽度与平均血小板体积改变的临床意义。方法入选诊断为急性心肌梗死(AMI)患者以及同期诊断为不稳定型心绞痛(UA)患者。共纳入127人,男性90人,女性37人。AMI组66例,UA组患者61人。比较两组临床基线资料,血生化检测指标,心功能,血小板和红细胞指标的差异。以红细胞分布宽度(RDW)50%累积频率二次分组,比较上述血生化和血细胞检测有意义指标的差异。分析AMI组和UA组中血小板与红细胞结果之间的相关性。建立AMI组中RDW为因变量的回归方程。结果在AMI和UA组中,大血小板比率,平均血小板体积(MPV)差异有明显的统计学意义(P0.01),RDW差异有明显的统计学意义(P0.05)。AMI组RDW与平均血小板体积相关分析有明显的统计学意义(r=0.34,P0.01)。RDW 50%累积频率分组中,MPV、大血小板比率、超敏C反应蛋白、D二聚体差异有明显的统计学意义(P0.05),氨基末端脑钠肽差异有明显的统计学意义(P0.01)。在AMI组中,以RDW为因变量,MPV、大血小板比率、超敏C反应蛋白、D二聚体、氨基末端脑钠肽自变量进行多元回归分析,回归方程RDW=0.19MPV+10.83。结论 AMI组RDW与MPV具有明显的相关性,在多元回归分析中,AMI组MPV可解释RDW改变。
[Abstract]:Objective to study the clinical significance of erythrocyte distribution width and mean platelet volume in patients with acute myocardial infarction. Methods patients with AMI and UAA with unstable angina pectoris were selected. A total of 127 patients were included, including 90 males and 37 females. 66 patients with UA in AMI group were 61 patients. The clinical baseline data, blood biochemical parameters, cardiac function, platelet and erythrocyte indexes were compared between the two groups. The 50% cumulative frequency of RDWN was divided into two groups to compare the difference of blood biochemical and hematopoietic detection. To analyze the correlation between platelet and erythrocyte results in AMI and UA groups. The regression equation of RDW as dependent variable in AMI group was established. Results in AMI and UA groups, large platelet ratio, There was significant difference in mean platelet volume (MPV). There was a significant difference in RDW between P0.01 and RDW. There was a significant correlation between RDW and mean platelet volume in the group of P0.05 and AMI. There was a statistically significant correlation between RDW and mean platelet volume. There was a significant difference in the ratio of MPV and large platelets in the group of 50% cumulative frequency of P0.01U / RDW, and there was no significant difference between RDW and RDW in the group with 50% cumulative frequency. The difference of D-dimer was statistically significant (P 0.05) and that of brain natriuretic peptide (BNP) at amino terminal was significantly different (P 0.01). In AMI group, RDW was used as dependent variable, large platelet ratio, high sensitive C-reactive protein D dimer and amino terminal brain natriuretic peptide were analyzed by multivariate regression analysis. The regression equation was RDWN 0.19 MPV 10.83. Conclusion there is a significant correlation between RDW and MPV in AMI group. MPV in AMI group can explain the change of RDW in multiple regression analysis.
【作者单位】：西安交通大学医学院第一附属医院心血管内科;
【基金】：国家自然科学基金(81170276)~~
【分类号】：R542.22

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