原发性高血压患者颈动脉粥样硬化与血清HCY水平和氧化应激的关系

发布时间：2018-06-22 02:55

本文选题：原发性高血压 + 颈动脉粥样硬化　；参考：《山东医药》2017年36期

【摘要】：目的探讨原发性高血压患者颈动脉粥样硬化与血清同型半胱氨酸(HCY)水平和氧化应激的关系。方法选择原发性高血压患者266例(观察组),其中有、无颈动脉粥样硬化者分别为167、99例。另选体检健康者50例作为对照组。采用全自动生化分析仪检测两组血清HCY水平及超氧化物歧化酶(SOD)活性,采用分光光度计检测血清丙二醛(MDA)水平。比较观察组有、无颈动脉粥样硬化者血清HCY、MDA水平及SOD活性;分析有动脉粥样硬化者颈动脉内膜中层厚度与血清HCY、MDA水平及SOD活性的关系。结果观察组血清HCY、MDA水平均明显高于对照组,SOD活性明显低于对照组(P均0.05)。观察组有颈动脉粥样硬化者血清HCY、MDA水平明显高于无颈动脉粥样硬化者,SOD活性明显低于无颈动脉粥样硬化者(P均0.05)。直线相关分析显示,观察组有颈动脉粥样硬化者颈动脉内膜中层厚度与血清HCY、MDA水平均呈正相关关系(r分别为0.575、0.462,P均0.05),与SOD活性呈负相关关系(r=-0.538,P0.05)。结论原发性高血压并颈动脉粥样硬化者血清HCY、MDA水平明显升高,SOD活性明显降低;血清HCY和氧化应激可能参与了原发性高血压患者颈动脉粥样硬化的发生、发展。
[Abstract]:Objective to investigate the relationship between carotid atherosclerosis and serum homocysteine (HCY) and oxidative stress in patients with essential hypertension. Methods 266 patients with essential hypertension (observation group) were selected, including 16799 patients without carotid atherosclerosis. 50 healthy persons were selected as control group. The serum HCY level and superoxide dismutase (SOD) activity were measured by automatic biochemical analyzer and the serum malondialdehyde (MDA) level was detected by spectrophotometer. The levels of serum HCYO MDA and SOD activity in patients without carotid atherosclerosis were compared, and the relationship between intima-media thickness of carotid artery and serum HCYN MDA level and SOD activity in patients with atherosclerosis were analyzed. Results the level of serum HCYO MDA in the observation group was significantly higher than that in the control group (P 0.05). The level of serum HCYO MDA in patients with carotid atherosclerosis was significantly higher than that in patients without carotid atherosclerosis (P 0.05). Linear correlation analysis showed that there was a positive correlation between carotid intima-media thickness and serum HCYMDAin patients with carotid atherosclerosis (r = 0.5750.462, P 0.05), and a negative correlation with SOD activity (r = 0.538P 0.05). Conclusion the level of serum HCYO MDA in patients with essential hypertension complicated with carotid atherosclerosis was significantly increased and SOD activity was significantly decreased, and serum HCY and oxidative stress might be involved in the occurrence and development of carotid atherosclerosis in patients with essential hypertension.
【作者单位】：茌平县人民医院;聊城市东昌府人民医院;山东大学附属省立医院;
【分类号】：R544.11

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