急性心肌梗死患者行经皮冠状动脉介入治疗术前使用替格瑞洛与氯吡格雷的对比研究

发布时间：2018-06-23 18:24

本文选题：心肌梗死 + 血管成形术　；参考：《中国全科医学》2017年S1期

【摘要】：目的探讨术前使用替格瑞洛与氯吡格雷对急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗(PCI)术的效果。方法选择2015年11月—2016年11月金华市中心医院行PCI的AMI患者250例,将术前使用氯吡格雷的125例患者设为对照组,术前使用替格瑞洛的125例设为观察组。比较两组患者术前、术后30 min、2 h、1d、2 d、7 d血小板聚集率,并比较术后心肌梗死溶栓治疗(TIMI)血流分级及不良反应发生情况。结果对照组术后2 h、1 d、2 d、7 d血小板聚集率均低于术前,差异有统计学意义(P0.05);观察组术后30 min、2 h、1 d、2 d、7 d血小板聚集率均低于术前,差异有统计学意义(P0.05)。观察组术后30 min、2 h、1 d血小板聚集率低于对照组,差异有统计学意义(P0.05)。两组术后TIMI血流分级比较,差异无统计学意义(P0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P0.05)。结论在对AMI患者行PCI术前使用替格瑞洛能降低术后早期血小板聚集率,相较于氯吡格雷不良反应发生率更低,安全性更高。
[Abstract]:Objective to investigate the effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) using tigrilol and clopidogrel before operation. Methods 250 AMI patients who received PCI in Jinhua Central Hospital from November 2015 to November 2016 were selected, 125 patients who were treated with clopidogrel before operation as control group and 125 patients who were treated with tigrilol before operation as observation group. The platelet aggregation rate was compared between the two groups before operation and 30 minutes after operation. The blood flow grading and adverse reactions of thrombolytic therapy (TIMI) were compared. Results the platelet aggregation rate in the control group was significantly lower than that in the preoperative group (P0.05), and the platelet aggregation rate in the observation group was significantly lower than that in the preoperative group (P0.05). The platelet aggregation rate in the observation group was significantly lower than that in the control group at 30 min and 2 h after operation (P0.05). There was no significant difference in TIMI blood flow grade between the two groups (P0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P0.05). Conclusion the use of tigrilol before PCI in AMI patients can reduce the early postoperative platelet aggregation rate, compared with clopidogrel, the incidence of adverse reactions is lower, and the safety is higher than that of clopidogrel.
【作者单位】：浙江省金华市中心医院;
【分类号】：R542.22

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