瑞舒伐他汀钙联合美托洛尔对老年心力衰竭患者心率变异性的影响

发布时间：2018-06-25 00:52

本文选题：瑞舒伐他汀钙 + 美托洛尔　；参考：《中国老年学杂志》2017年15期

【摘要】：目的探讨瑞舒伐他汀钙联合美托洛尔对老年心力衰竭患者心率变异性的影响。方法老年心力衰竭患者100例,依据随机数表法随机分为他汀洛尔组和他汀常规组,每组50例,他汀常规组给予洋地黄、抗血小板、利尿剂、血管紧张素转换酶抑制剂等基础治疗和10 mg瑞舒伐他汀钙治疗,他汀洛尔组在此基础上给予美托洛尔治疗,采用动态心电图检测心率变异性[正常R-R间期标准差(SDNN)、R-R间期差值高于50 ms部分占比(RNN50)、5 min正常R-R间期平均值标准差(SDANN)、连续5 min R-R间期差值均方根(r MSSD)],采用酶联免疫吸附法(ELISA)检测血清C反应蛋白(CRP)、白细胞介素(IL)-6、B型利钠肽(BNP)水平,统计分析所有患者治疗前后心功能、SDNN、RNN50、SDANN、r MSSD和血清CRP、IL-6、BNP水平及治疗期间不良反应发生情况。结果他汀洛尔组治疗有效率明显高于他汀常规组(P0.05),但两组治疗期间均无明显不良反应发生;治疗后,他汀洛尔组患者SDNN、RNN50、SDANN、r MSSD水平明显高于他汀常规组(P0.05);他汀洛尔组血清CRP、IL-6、BNP水平明显低于他汀常规组(P0.05)。结论瑞舒伐他汀钙联合美托洛尔治疗可有效提高老年心力衰竭患者的疗效,改善患者的心功能和心率变异性及机体炎症状态且具有良好的安全性。
[Abstract]:Objective to investigate the effects of recuvastatin calcium and metoprolol on heart rate variability in elderly patients with heart failure. Methods 100 elderly patients with heart failure were randomly divided into two groups: statin group (n = 50) and statin group (n = 50). Basic therapy such as angiotensin converting enzyme inhibitor and 10 mg of recuvastatin calcium were given to metoprolol in the statinolol group. Heart rate variability (HRV) was detected by dynamic electrocardiogram [normal R-R interval standard deviation (SDNN50) > 50ms partial duty ratio (RNN50) or 5 min normal R-R interval mean deviation (SDANN), continuous 5 min R-R interval mean square root (rMSSD)], enzyme linked immunosorbent assay (Elisa) was used. The levels of serum C-reactive protein (CRP) and interleukin (IL) -6B natriuretic peptide (BNP) were measured by Elisa. The levels of SDNN50 RN50 SDANNNr MSSD and serum CRP IL-6 BNP were statistically analyzed in all patients before and after treatment and the occurrence of adverse reactions during the treatment. Results the effective rate of statinolol group was significantly higher than that of statin routine group (P0.05), but there were no significant adverse reactions in both groups. The level of SDNNN50 RN50 SDANNnnmdr MSSD in statinolol group was significantly higher than that in statin routine group (P0.05), and the level of serum CRP IL-6 + BNP in statinolol group was significantly lower than that in statin routine group (P0.05). Conclusion Risuvastatin calcium combined with metoprolol can effectively improve the efficacy of heart failure in elderly patients, improve heart function, heart rate variability and inflammatory state of the body, and has good safety.
【作者单位】：海南医学院第一附属医院急诊科;海南医学院第一附属医院中医科;
【基金】：2014年海南省自然科学基金(No.0104777039)
【分类号】：R541.6

【相似文献】