心脏X综合征患者血清半乳糖凝集素3的表达和价值研究

发布时间：2018-06-26 01:00

本文选题：心脏X综合征 + 半乳糖凝集素　；参考：《临床心血管病杂志》2017年04期

【摘要】：目的:通过检测心脏X综合征(CSX)患者血清半乳糖凝集素3(Galectin-3)水平,探讨其与CSX发病的相关性及临床意义。方法:纳入115例CSX患者(CSX组)和74名健康对照者(对照组),测定血清Galectin-3和高敏C反应蛋白(hs-CRP)及一些生化指标的浓度。结果:CSX患者血清Galectin-3浓度较对照组高(CSX组:0.90ng/ml,IQR:0.40~1.70ng/ml;对照组:0.40ng/ml,IQR:0.36~0.44ng/ml;P0.0 001)。单因素Logistic分析显示,LnGalectin-3、Ln空腹葡萄糖、Lnhs-CRP、Ln尿酸的血清浓度与冠心病家族史都与CSX相关。多因素Logistic回归分析显示,LnGalectin-3、冠心病家族史、空腹血糖、Lnhs-CRP和Ln血尿酸是CSX的独立预测因子。糖尿病、高血压与CSX无明显相关性。Pearson相关分析表明血清LnGalectin-3与Ln hs-CRP显著正相关(r=0.16,P=0.03)。结论:CSX患者中血清Galectin-3浓度明显升高,Galectin-3表达与hs-CRP相关。
[Abstract]:Objective: to investigate the correlation between galectin-3 and CSX and its clinical significance by detecting the serum galectin-3 level in patients with cardiac X syndrome (CSX). Methods: serum Galectin-3, Gao Min C-reactive protein (hs-CRP) and some biochemical indexes were measured in 115 CSX patients (CSX group) and 74 healthy controls (control group). Results the serum Galectin-3 concentration of the patients with CSX was higher than that of the control group (1: 0.90 ng / ml IQR: 0.40ng / ml; the control group: 0.40 ng / ml / ml = 0.36 ng / ml / ml = 0.44 ng / ml / ml P 0.0001). Univariate logistic analysis showed that LnGalectin-3Ln fasting glucose Lnhs-CRPnuric acid concentration and family history of coronary heart disease were all correlated with CSX. Multivariate logistic regression analysis showed that LnGalectin-3, family history of coronary heart disease, fasting blood glucose, Lnhs-CRP and Ln serum uric acid were independent predictors of CSX. There was no significant correlation between diabetes mellitus, hypertension and CSX. Pearson correlation analysis showed that serum LnGalectin-3 was positively correlated with Lnhs-CRP (r = 0.16). Conclusion the level of Galectin-3 in serum of patients with CSX was significantly higher than that of patients with CSX, and the expression of Galectin-3 was correlated with hs-CRP.
【作者单位】：海南省人民医院老年病科;武汉大学人民医院心血管内科;
【分类号】：R541

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