ABO血型分布与冠心病的相关性研究

发布时间：2018-06-28 00:36

本文选题：冠心病 + ABO血型　；参考：《宁夏医科大学》2017年硕士论文

【摘要】：目的:研究ABO血型与冠心病的相关关系。方法:收集2013年3月至2016年3月在我院行冠状动脉造影(CAG)病例资料,设置病例组和对照组,病例组为任意1支≥50%,余归为对照组。记录CAG患者的ABO血型,统计并分析ABO血型与其CAG结果相关关系。并将冠心病组分为单支、双支、多支病变组,通过每组中ABO血型的构成比分析冠状动脉病变支数与血型分布的关系。利用Gensini积分明确ABO血型分布与冠状动脉狭窄的关系。研究冠心病与ABO血型及其各危险因素之间的相关关系采用logistic回归分析模型,P0.05为差异有统计学意义。结果:1.565例已明确血型的患者中,统计发现两组中年龄、性别、吸烟率、肥胖指数、吸烟率的P均0.05,差异均无统计学意义。而糖尿病患病率、高脂血症患者比例,P均0.05,差异有统计学意义。2.对冠心病组和对照组ABO血型分布的进行统计分析,两组中ABO血型分布差异有统计学意义(P0.05)。两组间A型血与非A型血的分布差异有统计学意义(P0.01)、O型血与非O型血的分布差异有统计学意义(P0.05)。两组间B型血与非B型血,AB型血与非AB型血分布差异均无统计学意义。logistic多元回归模型分析ABO血型分布与CHD的关系提示A血型者较O血型者患冠心病的风险高且差异有统计学意义(P0.05)。在冠心病各亚组间比较发现,冠状动脉病变支数越多,A型血患者的比例越高。在每一亚组内A型血所占比例均最高,O型血比例最低。研究发现A型组的Gensini积分最高。结论:1.ABO血型可能与冠心病发病存在一定的相关性,且A型可能较其它血型患冠心病的风险高;2.A型血冠状动脉病变程度较其它血型重。
[Abstract]:Objective: to study the relationship between ABO blood group and coronary heart disease. Methods: coronary angiography (CAG) was performed in our hospital from March 2013 to March 2016. Case group and control group were set up. ABO blood groups of CAG patients were recorded, and the correlation between ABO blood groups and CAG results was analyzed. The coronary artery disease was divided into single, double and multi-vessel groups. The relationship between the number of coronary artery disease branches and the distribution of blood group was analyzed by the ratio of ABO blood group in each group. The relationship between ABO blood group distribution and coronary artery stenosis was determined by Gensini integral. To study the correlation between coronary heart disease (CHD) and ABO blood type and its risk factors, the logistic regression model was used to analyze the correlation between them. Results the age, sex, smoking rate, obesity index, smoking rate of the two groups were all 0.05, and there was no significant difference between the two groups in terms of age, sex, smoking rate and smoking rate (P < 0.05). The prevalence of diabetes mellitus and the proportion of hyperlipidemia patients were 0.05, the difference was statistically significant. The distribution of ABO blood group in coronary heart disease group and control group was statistically analyzed. The difference of ABO blood group distribution between the two groups was statistically significant (P0.05). There was significant difference between the two groups in the distribution of type A blood and non-type A blood (P0.01). There was significant difference between O type blood and non-O type blood distribution (P0.05). There was no significant difference between the distribution of type B blood and non-type B blood between the two groups. Logistic regression model analysis of the relationship between ABO blood group distribution and CHD suggests that the risk of coronary heart disease is higher and worse in A blood group than in O blood group. The difference was statistically significant (P0.05). Compared with each subgroup of coronary heart disease, the more branches of coronary artery disease, the higher the proportion of patients with type A blood. In each subgroup, the proportion of type A blood was the highest and the proportion of type O blood was the lowest. It was found that type A group had the highest Gensini integral. Conclusion 1. ABO blood group may be associated with coronary heart disease, and type A may have a higher risk of coronary heart disease than other blood groups. 2. The severity of coronary artery disease of type A is heavier than that of other blood groups.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4

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