铁过载相关机制的研究在MDS中的重要意义

发布时间：2018-06-28 03:51

本文选题：骨髓增生异常综合征 + 铁过载　；参考：《中国实验血液学杂志》2017年01期

【摘要】：骨髓增生异常综合征(myelodysplastic syndromes,MDS)是起源于造血干细胞的克隆性疾病,表现为造血干细胞的发育异常和无效造血,导致外周血细胞计数减少、幼稚细胞增多及高风险转化为急性髓系白血病。MDS是血液系统常见恶性肿瘤之一,尚无有效的治愈手段,对人类健康危害很大。MDS中存在明显的铁过载现象,且铁过载能够影响MDS患者的总体生存时间及白血病转化风险,而对MDS患者进行祛铁治疗可一定程度地改善患者的预后。因此,MDS中铁过载的研究引起了广大学者的重视。迄今为止,大量研究表明输血、无效造血、基因改变、线粒体凋亡及ROS等与铁过载发生有密切关系,研究这些因素与铁过载的关系对于指导MDS中祛铁治疗具有重要意义。本文就铁过载发生的相关机制及其在MDS中的重要意义的最新研究进展作一综述。
[Abstract]:Myelodysplastic syndromes syndrome (MDS) is a clonal disease originating from hematopoietic stem cells, which is characterized by abnormal development of hematopoietic stem cells and ineffective hematopoiesis, resulting in a decrease in the number of peripheral blood cells. The proliferation of infantile cells and the high risk of transforming into acute myeloid leukemia. MDS is one of the common malignant tumors in the blood system. There is no effective cure and there is obvious iron overload phenomenon in MDS, which is harmful to human health. Iron overload can affect the overall survival time of MDS patients and the risk of leukemia transformation, and the treatment of removing iron can improve the prognosis of MDS patients to some extent. Therefore, the study of iron overload in MDS has attracted the attention of many scholars. Up to now, a large number of studies have shown that blood transfusion, ineffective hematopoiesis, gene change, mitochondrial apoptosis and Ros are closely related to iron overload. It is important to study the relationship between these factors and iron overload in order to guide the treatment of iron removal in MDS. In this paper, the mechanism of iron overload and its significance in MDS are reviewed.
【作者单位】：上海交通大学附属第六人民医院血液科;
【分类号】：R551.3

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