ACE和ACE2基因多态性与冠心病的相关性

发布时间：2018-06-29 13:52

本文选题：血管紧张素转化酶基因 + 血管紧张素转化酶Ⅱ基因　；参考：《中国老年学杂志》2017年16期

【摘要】：目的探讨血管紧张素转化酶(ACE)基因和ACE2基因遗传变异与中国北方汉族人群冠心病(CHD)的关系。方法选择在吉林大学第一医院确诊并住院的246例CHD患者和同期进行健康体检的251例正常人为研究对象,采用聚合酶链式反应-限制性片段长度多态性(PCRRFLP)技术检测ACE基因rs4461142位点及ACE2基因rs1514283位点的多态性并进行统计分析。结果病例组和对照组高血压、糖尿病所占的比例具有统计学差异(P0.05);两组rs4267385位点、rs1514283位点等位基因和基因型频数分布无统计学差异(P0.05)。结论 ACE基因rs4267385位点和ACE2基因rs1514283位点可能不是中国北方汉族人群CHD的易感位点。
[Abstract]:Objective to investigate the relationship between angiotensin converting enzyme (ACE) gene and ACE2 gene genetic variation and coronary heart disease (CHD) in Chinese Han population. Methods 246 CHD patients who were diagnosed and hospitalized in the first Hospital of Jilin University and 251 healthy people who underwent physical examination at the same time were selected as the study subjects. Polymerase chain reaction-restriction fragment length polymorphism (PCR RFLP) was used to detect the polymorphism of ACE gene rs4461142 locus and ACE2 gene rs1514283 locus. Results there was significant difference in the proportion of hypertension and diabetes between the case group and the control group (P0.05), while there was no significant difference in alleles and genotype frequencies of rs1514283 at rs4267385 locus between the two groups (P0.05). Conclusion ACE gene rs4267385 locus and ACE2 gene rs1514283 locus may not be susceptible to CHD in Han population of northern China.
【作者单位】：吉林大学中日联谊医院急诊科;吉林大学公共卫生学院劳动卫生与环境卫生学教研室;江西省肿瘤医院;
【基金】：教育部高校博士点专项基金(No.20100061110071)
【分类号】：R541.4

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