降压药物联合高压氧治疗原发性高血压及减少并发症的临床效果分析

发布时间：2018-06-30 05:37

本文选题：降压药 + 高压氧　；参考：《东南大学学报(医学版)》2017年05期

【摘要】：目的:探讨降压药物联合高压氧治疗原发性高血压的临床效果及减少并发症的效果。方法:选取本院2014年1月至2015年1月收治的110例原发性高血压疾病患者,采用随机数字表法分为试验组和对照组各55例,试验组采用降压药物联合高压氧治疗,对照组仅采取降压药物治疗,观察两组治疗后3个月的血压控制情况,并对患者进行为期1年的随访观察,观察患者心脏病发作的发生情况。结果:治疗前试验组和对照组的24 h平均收缩压(m SBP)、24 h平均舒张压(m DBP)、日间平均收缩压(d SBP)、日间平均舒张压(d DBP)、夜间平均收缩压(n SBP)和夜间平均舒张压(n DBP)测定值差异均无统计学意义(P0.05);治疗后试验组的m SBP、m DBP、d SBP、d DBP、n SBP、n DBP测定值显著低于对照组(P0.05)。治疗前试验组和对照组的一氧化氮(NO)、内皮素-1(ET-1)测定值差异均无统计学意义(P0.05);治疗后试验组NO测定值显著高于对照组(P0.05),ET-1测定值显著低于对照组(P0.05)。对两组患者进行1年随访观察,试验组心脏并发症发生率为9.43%,与对照组的21.15%差异无统计学意义(P0.05)。结论:降压药物联合高压氧治疗原发性高血压的降压效果更加显著,对并发症减少效果不明显,需要进一步延长随访时间。
[Abstract]:Objective: to investigate the clinical effect of hypotensive drugs combined with hyperbaric oxygen in the treatment of essential hypertension. Methods: 110 patients with essential hypertension from January 2014 to January 2015 were randomly divided into two groups: the experimental group (55 cases) and the control group (55 cases). The experimental group was treated with antihypertensive drugs combined with hyperbaric oxygen (HBO). The patients in the control group were treated with antihypertensive drugs only. The blood pressure control was observed 3 months after treatment and the patients were followed up for one year to observe the occurrence of heart attack. Results: 24 h mean systolic blood pressure (mSBP), 24 h mean systolic blood pressure (mDBP), day mean systolic blood pressure (d SBP), daytime mean diastolic blood pressure (d DBP), night mean systolic blood pressure (n SBP) and night mean diastolic blood pressure (n DBP) were measured in the experimental group and control group before treatment. There was no significant difference between the two groups (P0.05); after treatment, the mSBPnDBPnDBP in the experimental group was significantly lower than that in the control group (P0.05). There was no significant difference in nitric oxide (no) and endothelin-1 (ET-1) between the experimental group and the control group before treatment (P0.05), and after treatment, the level of no in the experimental group was significantly higher than that in the control group (P0.05), and that in the control group was significantly lower than that in the control group (P0.05). Two groups of patients were followed up for one year, the incidence of cardiac complications in the trial group was 9.43 and there was no significant difference between the control group and the control group (21.15%) (P0.05). Conclusion: the antihypertensive effect of hypotensive drugs combined with hyperbaric oxygen is more significant, but the effect of reducing complications is not obvious, so it is necessary to prolong the follow-up time.
【作者单位】：青海省药品采购中心药品科;青海省人民医院检验科;
【分类号】：R544.11

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