Salusin-β对心肌梗死大鼠凋亡及氧化应激的影响

发布时间：2018-07-01 13:25

本文选题：Salusin-β + 心肌梗死　；参考：《中国老年学杂志》2017年23期

【摘要】：目的研究Salusin-β改善心肌梗死大鼠发病及相关凋亡及氧化应激机制。方法 Wistar大鼠随机分为假手术组,模型组及治疗组(给予Salusin-β干预),模型组和治疗组为心肌梗死模型大鼠。观察各组心功能、组织病理学改变、凋亡情况及氧化应激情况。结果假手术组相比,模型组及治疗组收缩压(SBP)、舒张压(DBP)及左室舒张压(LVSP)显著降低,左室舒张末压(LVEDP)显著升高(均P0.05);与模型组相比,治疗组SBP、DBP及LVSP显著升高,LVEDP显著降低(P均0.05)。假手术组心肌组织细胞结构完整,肌纤维排列整齐;模型组细胞排列紊乱,水肿变形严重,肌纤维排列紊乱,间质充血水肿;治疗组病理学改变同模型组,但病变程度均减轻。假手术组基本不存在凋亡情况,模型组及治疗组凋亡情况显著增加;相比于模型组,治疗组凋亡显著降低。与假手术组相比,模型组及治疗组心肌组织Bcl-2蛋白表达显著降低,Bax蛋白表达显著升高(P0.05);与模型组相比,治疗组Bcl-2蛋白表达显著升高,Bax蛋白表达显著降低。与假手术组相比,模型组及治疗组SOD含量显著降低,MDA含量表达显著升高(均P0.05);与模型组相比,治疗组SOD含量显著升高,MDA含量表达显著降低(均P0.05)。结论 Salusin-β可通过改善心肌梗死大鼠心功能,抑制心肌细胞凋亡,改善心肌组织氧化应激从而发挥治疗心肌梗死疾病的作用。
[Abstract]:Objective to study the effect of Salusin- 尾 on the pathogenesis, apoptosis and oxidative stress in rats with myocardial infarction. Methods Wistar rats were randomly divided into sham-operation group, model group and treatment group (treated with Salusin- 尾). Model group and treatment group were treated with myocardial infarction model rats. Cardiac function, histopathological changes, apoptosis and oxidative stress were observed. Results systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular diastolic pressure (LVSP) and left ventricular end-diastolic pressure (LVEDP) in the model group and the treatment group were significantly lower than those in the sham operation group (P0.05), and SBP, DBP and LVSP in the treatment group were significantly higher than those in the model group (P 0.05). In sham-operation group, the structure of myocardial tissue cells was complete and the muscle fibers were arranged neatly; the cells in model group were disordered, edema was deformed seriously, and interstitial hyperemia and edema were serious; the pathological changes of treatment group were the same as that of model group, but the degree of pathological changes were all reduced. The apoptosis of model group and treatment group was significantly increased, compared with model group, the apoptosis of treatment group was significantly lower than that of model group. Compared with sham operation group, the expression of Bcl-2 protein in model group and treatment group was significantly lower than that in model group (P0.05), and the expression of Bcl-2 protein in treatment group was significantly higher than that in model group (P0.05). Compared with sham-operation group, SOD content in model group and treatment group decreased significantly (all P0.05), and SOD content in treatment group increased significantly compared with model group (P0.05). Conclusion Salusin- 尾 may play a role in the treatment of myocardial infarction by improving cardiac function, inhibiting cardiomyocyte apoptosis and improving oxidative stress of myocardial tissue.
【作者单位】：福建医科大学附属第二医院(泉州)心内二区;
【基金】：福建省卫生计生青年科研课题(2016-1-67)
【分类号】：R-332;R542.22

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