不同血压评估参数与老年高血压患者靶器官损害的关系

发布时间：2018-07-02 11:32

本文选题：高血压 + 诊室血压　；参考：《山东医药》2017年17期

【摘要】：目的探讨不同的血压评估参数与老年高血压患者靶器官损害之间的关系。方法选取886例老年高血压患者,对受试者的一般情况、病史资料等进行调查,并进行生化、动态血压、超声心动图、颈动脉超声、动脉硬化监测等检查,随访24个月。采用多元线性回归分别分析诊室、动态(24 h、白昼及夜间)、随访期峰值及平均血压、血压变异性与靶器官损害参数之间的关系。结果多元线性回归分析显示,除诊室、随访期峰值收缩压外,其余收缩压评估参数均与左心室重量指数呈线性正相关(P均0.05);除随访期峰值收缩压外,各血压评估参数均与颈总动脉内膜中层厚度、肱踝脉搏波传导速度呈线性正相关(P均0.05);随访期平均收缩压及各收缩压变异系数与尿微量白蛋白呈线性正相关(P均0.05)。结论诊室、动态、随访期平均收缩压及收缩压变异性均与靶器官损害参数存在一定程度的相关关系,其中随访期收缩压变异系数和夜间短时收缩压变异系数的关联性最强;随访期峰值收缩压与靶器官损害无关联性。
[Abstract]:Objective to investigate the relationship between different parameters of blood pressure assessment and target organ damage in elderly patients with hypertension. Methods A total of 886 elderly patients with hypertension were selected to investigate the general condition and history of hypertension. Biochemical examination, ambulatory blood pressure (ABBP), echocardiography, carotid ultrasound, and monitoring of arteriosclerosis were performed and followed up for 24 months. Multivariate linear regression was used to analyze the relationship between the parameters of target organ damage and the peak value, mean blood pressure, blood pressure variability and target organ damage parameters in clinic, dynamic (24 h, day and night). Results multiple linear regression analysis showed that the parameters of systolic blood pressure were positively correlated with left ventricular mass index except for the peak systolic blood pressure in the follow-up period (P 0.05), except for the peak systolic blood pressure in the follow-up period. The parameters of blood pressure were positively correlated with the intima-media thickness of common carotid artery and brachial ankle pulse wave velocity (P 0.05), and the mean systolic blood pressure and coefficient of variation of systolic blood pressure were positively correlated with urinary albumin (P 0.05). Conclusion there is a certain correlation between the mean systolic blood pressure and systolic blood pressure variability and the target organ damage parameters in the clinic, dynamic and follow-up period, and the correlation between the systolic blood pressure variation coefficient and the night short-term systolic blood pressure variation coefficient is the strongest in the follow-up period. There was no correlation between peak systolic blood pressure and target organ damage.
【作者单位】：南方医科大学;广州军区广州总医院;
【分类号】：R544.1

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