原发性高血压合并红细胞增多患者UA、Hs-CRP、FMD水平的关系

发布时间：2018-07-03 02:36

本文选题：原发性高血压 + 红细胞增多　；参考：《青海大学》2016年硕士论文

【摘要】：目的:通过对EH及其并发红细胞增多患者动态血压的监测,探讨EH患者BP水平和红细胞增多的关系;通过对上述患者UA、Hs-CRP和FMD的检测,探讨UA、Hs-CRP和FMD水平与高血压及其合并红细胞增多的关系;通过对不同红细胞数量的EH患者的UA、Hs-CRP和FMD值进行比较,探讨EH并发红细胞增多组红细胞数量与UA、Hs-CRP和FMD的相关性。方法:研究对象来自2014年12月-2015年12月青海大学附属医院的EH病人及其并发红细胞增多者。分为高血压组(A组)34例,男18例,女16例,平均岁数54.47±5.75岁;高血压合并红细胞增多组(B组)31例,男20例,女11例,平均岁数52.39±7.68岁。采集受试者的病史,检测UA、Hs-CRP、FMD、FPG、TCH、TG、24SBP、24DBP、RBC和HGB,分析比较两组病人一般临床指标的差异,和两组病人UA、Hs-CRP、FMD水平变化及B组红细胞水平与UA、Hs-CRP和FMD相关性。结果:一般资料、24SBP、24DBP和24△BP差两组比较,差异无统计学意义(均P0.05)。两组UA、Hs-CRP比较,B组高于A组,FMD低于A组,差异有统计学意义(P0.05),Pearson分析结果显示B组RBC与UA、Hs-CRP呈正性相关(r=0.92,r=0.94,P0.05),与肱动脉介导的血管内皮功能(FMD)呈负性相关(r=-0.97,P0.05)。结论:病人RBC与UA、Hs-CRP、FMD存在相关性。红细胞增多可能是UA、Hs-CRP、FMD的影响因素。控制红细胞数量对EH患者血压控制及其不良心血管事件的发生有重要意义。
[Abstract]:Objective: to investigate the relationship between BP level and erythrocytosis in EH patients by monitoring ambulatory blood pressure (ABBP) in EH patients, and to detect UAHs-CRP and FMD in EH patients. To investigate the relationship between the levels of UAHs-CRP and FMD and hypertension and their association with erythrocytosis, to compare the values of UAHs-CRP and FMD in EH patients with different erythrocyte counts, and to explore the correlation between the number of RBC and UAHs-CRP and FMD in EH complicated with EH. Methods: EH patients from the affiliated Hospital of Qinghai University from December 2014 to December 2015 and their patients with polycythemia were studied. The patients were divided into hypertension group (group A, n = 34), male (n = 18), female (n = 16, mean age 54.47 卤5.75 years), hypertension with polycythemia (group B, n = 31), male (n = 20), female (n = 11), mean age (52.39 卤7.68 years). The patients' history was collected, and the RBC and HGBs of TCHG (TCHG) 24SBPU 24DBPU and HGBwere detected, and the changes of UAHs-CRPU FMD and the correlation between RBC and UAHs-CRP and FMD in group B were compared between the two groups. Results: there was no significant difference between 24 SBP 24 DBP and 24 BP difference in general data (P0.05). The FMD of group B was higher than that of group A (P 0.05). Pearson analysis showed that there was a positive correlation between RBC and UAHs-CRP in group B (P 0.05), and a negative correlation with vascular endothelial function (FMD) mediated by brachial artery (P 0.05). Conclusion: there is a correlation between RBC and FMD in UAV Hs-CRP. Erythrocythemia may be the influencing factor of FMD in UAV Hs-CRP. Controlling the number of erythrocytes is of great significance to the control of blood pressure and the occurrence of adverse cardiovascular events in EH patients.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R544.11;R555.1

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