氨氯地平联合阿托伐他汀钙片治疗老年高血压合并冠心病患者的临床疗效及对血清Apelin、Hcy水平的影响

发布时间：2018-07-05 02:55

本文选题：氨氯地平 + 阿托伐他汀钙片　；参考：《中国老年学杂志》2017年13期

【摘要】：目的观察氨氯地平联合阿托伐他汀钙片治疗老年高血压合并冠心病患者的临床疗效及对患者血清孤独G蛋白耦联受体配体(Apelin)、同型半胱氨酸(Hcy)水平的影响。方法按照随机数字法将96例高血压合并冠心病的老年患者分为观察组和对照组,每组48例。对照组给予氨氯地平治疗,观察组在给予氨氯地平的基础上联合阿托伐他汀钙片治疗,治疗6 w后,比较两组患者的临床疗效,同时比较2组患者治疗前后血脂相关指标总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及血清Apelin、Hcy水平的变化情况。结果观察组患者的疗效均明显优于对照组(P0.05);两组患者治疗前,血清TC、TG、LDL-C、HDL-C及Apelin、Hcy水平组间比较均无统计学差异,治疗6 w后,观察组在相关血脂指标水平明显低于对照组(P0.05),而HDL-C水平略高于对照组(P0.05);观察组患者的血清Apelin、HCY水平治疗后与对照组比较,差异有统计学意义(P0.05)。结论氨氯地平联合阿托伐他汀钙片治疗老年高血压合并冠心病,可有效控制血脂、血压及改善心脏功能,治疗风险小,总有效率高。
[Abstract]:Objective to observe the clinical efficacy of amlodipine combined with Atto vastatin calcium tablets in the treatment of elderly patients with hypertension and coronary heart disease (CHD) and to observe the effect of amlodipine on serum homocysteine (Hcy) level of isolated G protein-coupled receptor ligand (Apelin),). Methods 96 elderly patients with hypertension and coronary heart disease were randomly divided into observation group and control group with 48 cases in each group. The control group was treated with amlodipine, and the observation group was treated with Atto vastatin calcium tablet on the basis of amlodipine. After 6 weeks of treatment, the clinical efficacy of the two groups was compared. The changes of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and serum Apelinine Hcy were compared before and after treatment. Results the curative effect of the observation group was significantly better than that of the control group (P0.05), before treatment, there was no statistical difference between the two groups in the levels of serum TGG LDL-C and Apelin Hcy, and there was no significant difference between the two groups after 6 weeks of treatment. The serum levels of serum Apelin HCY in the observation group were significantly lower than those in the control group (P0.05), while HDL-C level was slightly higher than that in the control group (P0.05). Conclusion Amlodipine combined with Atto vastatin calcium tablets can effectively control blood lipids, blood pressure and improve heart function in elderly patients with hypertension and coronary heart disease.
【作者单位】：武汉市东西湖区人民医院心血管内科;
【分类号】：R541.4;R544.1

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