重组组织型纤溶酶原激活剂静脉溶栓治疗风湿性心脏病左心房内血栓脱落致脑梗死临床效果评价

发布时间：2018-07-05 05:53

本文选题：血栓溶解疗法 + 风湿性心脏病　；参考：《中国全科医学》2017年S2期

【摘要】：目的探讨重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗风湿性心脏病左心房内血栓脱落致脑栓塞的临床疗效。方法选取2014年8月—2016年8月东阳市人民医院收治的100例风湿性心脏病左心房内血栓脱落致脑栓塞患者,将患者随机分为观察组50例和对照组50例,对照组采用常规治疗,观察组在此基础上采用rt-PA静脉溶栓治疗,观察两组患者治疗效果,采用神经功能缺损评分(NIHSS)对治疗前、治疗后1 h、24 h、7 d、30 d进行评价。结果治疗前两组患者NIHSS比较,差异无统计学意义(P0.05),治疗后1 h、24 h、7 d、30 d观察组NIHSS均低于对照组(P0.05)。观察组总有效率高于对照组(P0.05)。结论 rt-PA静脉溶栓治疗风湿性心脏病左心房内血栓脱落致脑栓塞患者效果显著,可改善脑神经功能,值得临床推广。
[Abstract]:Objective to investigate the clinical efficacy of recombinant tissue plasminogen activator (rt-PA) intravenous thrombolytic therapy in the treatment of cerebral embolism in left atrium of rheumatic heart disease. Methods 100 patients with cerebral embolism caused by left atrial thrombolysis in the people's Hospital of Dongyang from August 2014 to August 2016 were randomly divided into the patients. The observation group 50 cases and the control group 50 cases, the control group adopted the routine treatment, the observation group was treated with rt-PA intravenous thrombolytic therapy on this basis, observed the effect of two groups of patients, using the nerve function defect score (NIHSS) before treatment, 1 h after treatment, 24 h, 7 D, 30 d, the results before the treatment of two groups of NIHSS, the difference was not statistically significant (P). 0.05), after treatment, 1 h, 24 h, 7 d, and 30 d in the observation group were lower than the control group (P0.05). The total effective rate of the observation group was higher than that of the control group (P0.05). Conclusion the effect of thrombolytic thrombolysis in the treatment of the left atrial thrombus in the patients with rheumatic heart disease caused cerebral embolism was significant, and the function of the cerebral deity was improved, and it was worthy of clinical promotion.
【作者单位】：浙江省东阳市人民医院;
【分类号】：R541.2;R743.33

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