坏死性淋巴结炎与干扰素γ诱导蛋白10、单核因子、FasL

发布时间：2018-07-05 14:31

本文选题：型坏死性淋巴结炎 + 干扰素γ诱导蛋白　；参考：《中华中医药学刊》2017年09期

【摘要】：目的:观察3型坏死性淋巴结炎患者的临床表现,探讨干扰素γ诱导蛋白10、单核因子、Fas L在3型坏死性淋巴结炎患者发病中的作用。方法:将HNL患者根据病理组织学分成增生(PT)、坏死(NT)和黄色瘤型(XT)3组,观察其临床表现,记录中医证候积分;抽取健康对照组和3组HNL患者外周血,用ELISA法检测血清IP-10、Mig、Fas L的含量。结果:PT、NT患者的中医症候积分明显高于XT患者,前两组与后者相比,有显著性差异(P0.05);坏死性淋巴结炎患者血清IP-10、Mig、Fas L均明显高于健康对照组(P0.01);PT、NT2型血清IP-10、Mig、Fas L明显高于XT型,差异有显著性意义(P0.05);IP-10、Mig、Fas L与淋巴结肿痛、体征呈正相关。结论:3组患者的临床表现存在差异;IP-10、Mig、Fas L可能参与了坏死性淋巴结炎发病过程,并与临床症状有相关性。
[Abstract]:Objective: to observe the clinical manifestations of type 3 necrotizing lymphadenitis and to investigate the role of interferon 纬 inducible protein 10 and monocyte factor FAS L in the pathogenesis of type 3 necrotizing lymphadenitis. Methods: according to histopathology, HNL patients were divided into three groups: hyperplasia (PT), necrosis (NT) and xanthoma (XT). The clinical manifestations of HNL were observed and the TCM syndromes score was recorded. Results the score of TCM symptom in the patients with NT was significantly higher than that in the patients with XT, and there was significant difference between the former two groups (P0.05), and the serum IP-10 and Migfas L in the patients with necrotizing lymphadenitis were significantly higher than those in the healthy controls (P0.01), and the levels of IP-10 and Migfas L in the patients with necrotizing lymphadenitis were significantly higher than those in the control group (P0.01). The difference was significant (P0.05). There was a positive correlation between Fas L of IP-10 and lymph node swelling and pain. Conclusion there are differences in clinical manifestations among the three groups of patients. IP-10 / Migfas L may be involved in the pathogenesis of necrotizing lymphadenitis and may be correlated with clinical symptoms.
【作者单位】：南京中医药大学附属南京市中西医结合医院;
【基金】：南京市科技局科技发展计划项目(201201058)
【分类号】：R551.2

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