冠脉内注射前列地尔对ST段抬高型心肌梗死急诊经皮冠状动脉介入效果的影响

发布时间：2018-07-08 11:50

本文选题：心肌梗死 + 前列地尔　；参考：《中国老年学杂志》2017年18期

【摘要】：目的探讨急诊经皮冠状动脉介入(PCI)冠脉内注射前列地尔对急性ST段抬高型心肌梗死(STEMI)患者心肌组织灌注水平和临床预后的影响。方法连续入选STEMI急诊PCI治疗的患者80例,随机分为对照组及治疗组各40例。对照组常规行PCI治疗,试验组在对照组治疗基础上开通血管后冠脉内注射前列地尔。观察两组心肌组织灌注水平及主要心血管事件(MACE)的发生情况。结果治疗组PCI术后梗死相关血管TIMI血流分级(TFG)Ⅲ级获得率及术后1 h ST段回落程度明显高于对照组,校正TIMI血流计数帧数(CTFC)显著少于对照组(P0.05);治疗组术中慢血流和院内MACE的发生率明显少于对照组,术中无复流及30 d的MACE与对照组无统计学差异(P0.05)。结论 STEMI患者PCI术中开通梗死相关血管后冠脉内注射前列地尔可改善心肌微循环,增加心肌灌注,减少慢血流及院内MACE。
[Abstract]:Objective to investigate the effect of intracoronary injection of alprostadil on myocardial perfusion and clinical prognosis in patients with acute ST segment elevation myocardial infarction (STEMI) by percutaneous coronary intervention (PCI). Methods 80 patients with STEMI emergency PCI were randomly divided into the control group and the treatment group (40 cases each). The control group was routinely treated with PCI. The results of myocardial perfusion level and major cardiovascular events (MACE) were observed in two groups of myocardial perfusion level and major cardiovascular events (MACE). Results in the treatment group, the rate of TIMI flow classification (TFG) grade III of infarct related blood vessels in the treatment group and the level of 1 h ST segment after the operation were significantly higher than those of the control group, and the correction of TIMI was significantly higher than that of the control group. The number of blood flow counting frames (CTFC) was significantly less than that of the control group (P0.05). The incidence of slow blood flow and MACE in the treatment group was significantly less than that in the control group. There was no significant difference between the 30 d and the control group (P0.05). Conclusion the myocardial microcirculation can be improved by intravascular injection of alprostadil after the opening of infarct related blood tube in PCI operation of STEMI patients. Increase myocardial perfusion, reduce slow blood flow and MACE. in hospital
【作者单位】：吉林省人民医院心内科;
【分类号】：R542.22

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