CA125、尿酸、总胆红素与老年慢性心力衰竭关系的探讨

发布时间：2018-07-14 09:30

【摘要】：目的:本研究以老年慢性心力衰竭患者为研究对象,监测其CA125、尿酸、总胆红素的水平,分析探讨CA125、尿酸、总胆红素对老年慢性心力衰是否具有诊断价值,及其与心功能分级的相关性,以期提供更多的客观依据供临床医师参考,对老年慢性心力衰竭的诊疗提供新的指导意义。方法:1.收集2015年06月至2016年06月于陕西省人民医院心内三科住院的符合条件的慢性心力衰竭患者临床资料,纳入符合条件的慢性心力衰竭患者供98例,以同期健康体检者52例作为对照组,按照Framingham心力衰竭诊断标准诊断的心衰组,将选取指标进行分析与对照组之间进行单因素及多因素分析,进一步分析有统计学意义的指标是否有诊断价值;CA125与BNP之间进行相关性分析。2.根据美国纽约心脏协会(NYHA)标准分级,将心衰组分为三组(1组:心功能I/II级、2组:心功能III级,3组.心功能IV级),分析所选取指标与心功能分级等级的相关性。所有数据均采用SPSS19.0软件进行统计分析,以P0.05为差异具有统计学上的显著性意义。结果:1.心衰组与对照组比较:BNP值对是否患病进行诊断的准确度高达83.5%,CA125对是否患病进行诊断的准确度高达73.8%。2.CA125与BNP的相关性分析:BNP和CA125之间存在着显著的正向相关关系,二者之间的相关系数为0.5660。3.各项指标与心功能分级的等级相关性分析:总胆红素与心功能分级相关系数为0.836,尿酸与心功能分级相关系数为0.463,BNP与心功能分级相关系数为0.488,CA125心功能分级相关系数为0.679。结论:1.BNP及CA125对分别对慢性心力衰竭具有诊断价值。2.慢性心力衰竭患者外周血清CA125、血尿酸、总胆红素含量随NYHA心功能分级增高,对于慢性心力衰竭患者症状的严重程度具有良好评价功能。
[Abstract]:Objective: to investigate the diagnostic value of CA125, uric acid and total bilirubin in elderly patients with chronic heart failure. In order to provide more objective basis for clinicians, and to provide new guidance for the diagnosis and treatment of chronic heart failure in the elderly. Method 1: 1. From June 2015 to June 2016, clinical data of eligible patients with chronic heart failure (CHF) were collected and 98 eligible CHF patients were included. In the same period, 52 healthy persons were used as the control group. The selected indexes were analyzed by single factor analysis and multivariate analysis between the two groups according to the diagnosis criteria of Fraingham heart failure. Further analysis of the statistical significance of whether there is diagnostic value of CA125 and BNP correlation analysis. 2. 2. According to the New York Heart Association (NYHA) standard classification, the heart failure group was divided into three groups (group 1: cardiac function I / II class 2: cardiac function class III). To analyze the correlation between the indexes selected and the grade of cardiac function. All the data were analyzed by SPSS 19.0 software, with P0.05 as the statistical significance. The result is 1: 1. Compared with the control group, the diagnostic accuracy of the ratio of BNP to the disease was as high as 83.5% and the accuracy of CA125 was as high as 73.8.2.The correlation between CA125 and BNP was significant positive correlation between BNP and CA125. The correlation coefficient between them is 0.5660.3. The correlation coefficient between total bilirubin and cardiac function grade was 0.836, and the correlation coefficient between uric acid and cardiac function grade was 0.463nb BNP and cardiac function grade was 0.488GCA 125, the correlation coefficient was 0.6799.The correlation coefficient between total bilirubin and cardiac function grade was 0.836, and the correlation coefficient between uric acid and cardiac function grade was 0.463g BNP. Conclusion 1. BNP and CA 125 have diagnostic value in chronic heart failure. The levels of serum CA 125, uric acid and total bilirubin in peripheral blood of patients with chronic heart failure were increased with NYHA cardiac function grade, which had a good function in evaluating the severity of symptoms in patients with chronic heart failure.
【学位授予单位】：延安大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.6

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