动脉粥样硬化发病的炎症机制的研究进展
发布时间：2018-07-14 10:58
【摘要】：动脉粥样硬化是临床常见疾病,是缺血性心脑血管病的主要病理基础。迄今为止,其发病机制尚未完全清楚,因而临床尚无有效而特异性的药物治疗。大量基础和临床研究表明,动脉粥样硬化是一种慢性炎症性疾病,是血管壁对各种损伤的一种异常反应,具有经典炎症变性、渗出及增生的特点。炎症反应贯穿动脉粥样硬化发病的各个阶段,可能是多种致动脉粥样硬化因素致病机制的共同环节或通路。炎症机制不但与动脉粥样硬化的发生发展有关,而且与动脉粥样硬化的多种并发症的发生密切相关。动脉粥样硬化的炎症类型包括生物性炎症、免疫性炎症和化学性炎症。动脉粥样硬化发病初期主要表现为急性渗出性炎症,而在进展期主要表现出慢性增生性炎症的特点。炎症反应中涉及多种炎症细胞、炎性细胞因子、炎性介质、黏附分子、趋化因子、生长因子等。现已证明,多种抗动脉粥样硬化药物具有抗炎作用,抗炎治疗已成为防治动脉粥样硬化的一种新途径。
[Abstract]:Atherosclerosis is a common clinical disease, is the main pathological basis of ischemic cardiovascular and cerebrovascular disease. So far, the pathogenesis of the disease has not been fully understood, so there is no effective and specific drug therapy. A large number of basic and clinical studies have shown that atherosclerosis is a chronic inflammatory disease, is an abnormal response of vascular wall to various injuries, and has the characteristics of classic inflammatory degeneration, exudation and proliferation. Inflammatory reaction runs through the various stages of atherosclerosis and may be the common link or pathway of the pathogenesis of various atherogenic factors. Inflammatory mechanism is not only related to the occurrence and development of atherosclerosis, but also closely related to the occurrence of various complications of atherosclerosis. Inflammatory types of atherosclerosis include biological inflammation, immune inflammation and chemical inflammation. Acute exudative inflammation is the main manifestation in the early stage of atherosclerosis, and chronic proliferative inflammation in the advanced stage. Inflammatory response involves many inflammatory cells, inflammatory cytokines, inflammatory mediators, adhesion molecules, chemokines, growth factors and so on. It has been proved that many anti-atherosclerotic drugs have anti-inflammatory effects and anti-inflammatory therapy has become a new way to prevent and treat atherosclerosis.
【作者单位】： 西安交通大学医学部基础医学院药理系;
【基金】：2007年国家自然科学基金(No.30772567) 2006年教育部博士学科点专项科研基金(No.20060698048) 2010年教育部博士学科点专项科研基金(No.20100201110053)~~
【分类号】：R543.5
[Abstract]:Atherosclerosis is a common clinical disease, is the main pathological basis of ischemic cardiovascular and cerebrovascular disease. So far, the pathogenesis of the disease has not been fully understood, so there is no effective and specific drug therapy. A large number of basic and clinical studies have shown that atherosclerosis is a chronic inflammatory disease, is an abnormal response of vascular wall to various injuries, and has the characteristics of classic inflammatory degeneration, exudation and proliferation. Inflammatory reaction runs through the various stages of atherosclerosis and may be the common link or pathway of the pathogenesis of various atherogenic factors. Inflammatory mechanism is not only related to the occurrence and development of atherosclerosis, but also closely related to the occurrence of various complications of atherosclerosis. Inflammatory types of atherosclerosis include biological inflammation, immune inflammation and chemical inflammation. Acute exudative inflammation is the main manifestation in the early stage of atherosclerosis, and chronic proliferative inflammation in the advanced stage. Inflammatory response involves many inflammatory cells, inflammatory cytokines, inflammatory mediators, adhesion molecules, chemokines, growth factors and so on. It has been proved that many anti-atherosclerotic drugs have anti-inflammatory effects and anti-inflammatory therapy has become a new way to prevent and treat atherosclerosis.
【作者单位】： 西安交通大学医学部基础医学院药理系;
【基金】：2007年国家自然科学基金(No.30772567) 2006年教育部博士学科点专项科研基金(No.20060698048) 2010年教育部博士学科点专项科研基金(No.20100201110053)~~
【分类号】：R543.5
【参考文献】
相关期刊论文 前10条
1 马亚兵;高海青;;微量元素与动脉粥样硬化[J];国外医学(老年医学分册);2006年06期
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4 陈q，
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