伴糖耐量异常的原发性高血压患者尿酸对血管损害的影响

发布时间：2018-07-20 11:30

【摘要】：目的：观察伴糖耐量异常的原发性高血压患者尿酸水平对颈动脉硬化及动脉僵硬度的影响。方法：选取2012年12月～2013年9月就诊于我院的原发性高血压患者513例,根据空腹血糖及餐后2h血糖分为糖耐量正常组267例、糖耐量异常组246例,通过一般资料的收集、血清学指标检测及动脉僵硬度相关指标的测定,探究尿酸对伴糖耐量异常的原发性高血压患者颈动脉硬化及动脉僵硬度的影响。结果：2组患者尿酸、空腹血糖、胆固醇、高密度脂蛋白、低密度脂蛋白、载脂蛋白B、碱性磷酸酶、糖化血红蛋白比较,差异均有统计学意义(t值分别为-11.732、-9.657、-3.033、2.934、-3.183、-4.531、-2.271、-5.093,P均0.05),颈动脉内膜中层厚度(IMT)、肱踝脉搏波传导速度(baPWV)及斑块发生率之间比较差异亦有统计学意义(t/χ2值分别为-3.999、-4.713、6.907,P均0.05),但左右两侧IMT、baPWV均无明显统计学差异(t值分别为-3.604、-3.729,-4.496、-4.810,P均0.05),2组ABI差异无统计学意义(P0.05)。BaPWV的多元Logistic回归分析示年龄、尿酸为动脉僵硬度的独立危险因素(分别为OR=1.115,95%CI1.084～1.146, OR=1.004,95%CI 1.000～1.007,P均0.05)。结论：对于伴有糖耐量异常的原发性高血压患者,应积极控制其血尿酸及血糖水平,以减少动脉硬化程度,进而减少血管的损害,防止心血管恶性事件的发生。
[Abstract]:Aim: to investigate the effect of uric acid level on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Methods: 513 patients with essential hypertension were selected from December 2012 to September 2013. According to fasting blood glucose and 2 h postprandial blood glucose, 267 patients with normal glucose tolerance and 246 patients with abnormal glucose tolerance were divided into two groups. To investigate the effect of uric acid on carotid arteriosclerosis and arterial stiffness in patients with essential hypertension with impaired glucose tolerance. Results comparison of uric acid, fasting blood glucose, cholesterol, high density lipoprotein, low density lipoprotein, apolipoprotein B, alkaline phosphatase, glycosylated hemoglobin, The differences were statistically significant (t = -11.732U -9.657U -3.033n 2.934U -3.183U -4.531U -2.271U -5.093g P 0.05), and there were also significant differences in carotid intima-media thickness (IMT), brachial ankle pulse velocity (baPWV) and plaque incidence (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively, P 0.05), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.999- 4.7136.907, respectively), but IMTBA PWV on both sides of the carotid artery was significantly different (t / 蠂 ~ 2 = -3.9999-4.7136.907, respectively). There was no significant difference in ABI between the two groups (t = -3.604 (t = -3.729) -4.496 ~ (-4.810) P 0.05). There was no significant difference between the two groups in ABI (P0.05) .BaPWV multiple logistic regression analysis showed that there was no significant difference in ABI between the two groups. Uric acid was an independent risk factor for arterial stiffness (OR1. 115 / 95 CI 1.084 / 1.146, OR1. 004 / 95CI = 1. 000 / 1.007, P = 0. 05). Conclusion: for essential hypertension patients with abnormal glucose tolerance, the levels of serum uric acid and blood glucose should be controlled actively to reduce the degree of arteriosclerosis, thereby reduce the damage of blood vessels and prevent the occurrence of malignant cardiovascular events.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.11
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本文编号：2133372