幽门螺杆菌和血浆基质金属蛋白酶-9与冠心病的相关性

发布时间：2018-07-26 20:43

【摘要】：目的探讨幽门螺杆菌(Hp)感染和血浆基质金属蛋白酶(MMP)-9与冠心病(CHD)的相关性。方法选择非CHD患者143例和CHD患者149例,CHD组根据病变支数又分为单支病变38例、双支病变46例、多支病变65支。所有病例行13C-呼气试验、血浆Hp抗体(Hp Ig G)及血浆MMP-9水平检测,并计算CHD组Gensini积分;同时收集病史、尿酸(UA)、血脂、高敏C反应蛋白、糖化血红蛋白(Hb A1c)等指标,评价Hp感染、MMP-9水平与CHD的相关性。结果两组吸烟、年龄、低密度脂蛋白、高敏C反应蛋白、同型半胱氨酸水平有统计学差异(P0.05);CHD组Hp感染δ值、MMP-9水平及Gensini积分明显高于非CHD组(P0.05).Hp感染δ值、MMP-9水平及Gensini积分随病变血管数增加而升高(P0.05)。Hp感染δ值、MMP-9与Gensini积分正相关(r=0.869、r=0.932,均P0.01),Hp感染δ值与MMP-9正相关(r=0.90,P0.01)。结论 Hp感染和MMP-9水平对CHD有一定的预测价值。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (Hp) infection and plasma matrix metalloproteinase (MMP)-9 and (CHD) in coronary heart disease. Methods 143 patients with CHD and 149 patients with CHD were divided into three groups: 38 patients with single vessel disease, 46 patients with double vessel disease and 65 patients with multiple vessel disease. All patients underwent 13C-breath test, plasma HP antibody (Hp Ig G) and plasma MMP-9 levels were measured, and Gensini scores in CHD group were calculated, and the clinical history, uric acid (UA), lipid, Gao Min C-reactive protein, glycosylated hemoglobin (HbA1c) and so on were collected. To evaluate the correlation between the level of MMP-9 and CHD in HP infected patients. Results smoking, age, low density lipoprotein, Gao Min C-reactive protein, There was significant difference in homocysteine level (P0.05). The level of MMP-9 and Gensini score of HP infection in CHD group were significantly higher than those in non-CHD group (P0.05). The level of MMP-9 and Gensini integral increased with the increase of the number of diseased blood vessels (P0.05) .Hp infection 未 value, MMP-9 and Gensini integral were positive phase higher than those in non-CHD group (P0.05) .Hp infection 未 value, MMP-9 and Gensini score were significantly higher than those in non-CHD group (P0.05). The 未 value of HP infection was positively correlated with MMP-9 (r = 0.869, r = 0.932, all P 0.01), and was positively correlated with MMP-9 (r = 0.90, P 0.01). Conclusion HP infection and MMP-9 level have certain predictive value for CHD.
【作者单位】：北京市门头沟区医院心内科;首都医科大学附属北京天坛医院心内科;北京市门头沟区医院检验科;
【基金】：北京市优秀青年基金项目(No.2011D008017000002)
【分类号】：R541.4

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