生活方式干预对心血管疾病危险因素的影响——美国HELPS项目成果

发布时间：2018-07-30 06:21

【摘要】：心血管疾病(CVD)一直是全世界最主要的死因。由于CVD等慢性疾病对健康的威胁越来越大,有必要开展生活方式干预项目以控制这些疾病的危险因素。本研究的目的是评估美国的重要慢病干预项目—HELPS治疗型生活方式改变(TLC)项目对减少CVD危险因素和其他慢性疾病的有效性。方法:140位大学教职工参加为期12周的HELPS TLC项目,干预前后用配对t检验对其体重、BMI、腰围(WC)、6分钟步行距离(6MWD)、空腹血脂和血糖进行测定和比较。结果:干预后,6MWD显著增加,总胆固醇(TC)和WC显著下降。对"高危"参与者进一步分析显示:BMI(-1.5±0.5,-3.9%)、TC(-22.8±4.0,-9.0%)、LDL(-14.1±4.9,9.3%)和血糖(-6.9±2.2,-6.1%)均显著下降;男性腰围(-4.5±0.8,-10%)显著减小,女性未见显著改变(-1.5±0.5,-4.0%)。此外,体重的变化与TC(r=0.43)、LDL(r=0.35)和血糖(r=0.44)的变化均显著相关。结论:参加12周的生活方式干预项目可以使CVD危险因素减少,特别是在CVD"高危"个体中。HELPS TLC项目的远期效果还待进一步深入研究。
[Abstract]:Cardiovascular disease (CVD) has been the leading cause of death in the world. As chronic diseases such as CVD pose a growing threat to health, lifestyle interventions are needed to control the risk factors for these diseases. The purpose of this study was to evaluate the effectiveness of the HELPS Therapeutic lifestyle change (TLC) program in reducing risk factors for CVD and other chronic diseases in the United States. Methods one hundred and forty faculty members participated in the 12-week HELPS TLC program. The body weight, (WC) 6-minute walking distance (6MWD), fasting blood lipid and blood glucose were measured and compared by paired t test before and after intervention. Results: after intervention, 6 MWD significantly increased, total cholesterol (TC) and WC decreased significantly. Further analysis of "high risk" participants showed that TC (-22.8 卤4.0 卤9.0%) and blood glucose (-6.9 卤2.2 卤-6.1%) were significantly decreased, waist circumference (-4.5 卤0.8 卤-10%) and waist circumference (-1.5 卤0.5 卤4.5% -4.0%) were significantly decreased in male (-22.8 卤4.0%) and blood glucose (-6.9 卤2.2 卤-6.1%) were significantly decreased in male (-22.8 卤4.0%), but not in female (-1.5 卤0.5% -4.0%). In addition, the changes of body weight were significantly correlated with the changes of TC (r = 0.43), LDL (r = 0.35) and blood glucose (r = 0.44). Conclusion: participating in a 12-week lifestyle intervention program can reduce the risk factors of CVD, especially in individuals at high risk of CVD. The long-term effects of the Helps TLC project need to be further studied.
【作者单位】： Wake森林大学运动与健康科学系;中山大学;
【分类号】：R54

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