低氧环境下慢性充血性心力衰竭患者脂肪因子水平变化对心室构型的影响

发布时间：2018-08-07 22:04

【摘要】：目的观察低氧环境下慢性心力衰竭(chronic heart faiture,CHF)患者脂肪因子趋化素(chemerin)、瘦素(leptin)、脂联素(adiponectin)水平的变化及对心室构型的影响。方法选择收住我科按美国纽约心脏病协会心功能分级标准确诊的CHF患者,按生活的海拔区分为2 260 m组CHF患者、健康对照组各67例和3 300 m组CHF患者、对照组各62例。检测血浆脂联素、趋化素、瘦素水平,计算平均室壁应力(mean wall stress,MWS)和心室质量指数(left ventricular mass index,LVMI)。结果海拔3 300 m组CHF患者和健康对照组脂联素、趋化素、瘦素水平和MWS、LVMI均高于2 260 m组(P0.01);同一海拔高度CHF患者脂联素、趋化素、瘦素水平和MWS、LVMI高于健康对照组;MWS和LVMI与脂联素、趋化素、瘦素水平均呈正相关(P0.01)。结论低氧环境下CHF患者脂肪因子脂联素、趋化素、瘦素水平的变化参与了CHF发生、发展的病理生理过程。
[Abstract]:Objective To observe the changes of adipose factor chemoattractant (Chemerin), leptin (leptin) and adiponectin (adiponectin) level in patients with chronic heart failure (chronic heart faiture, CHF) in hypoxic environment and the effect on ventricular configuration. Methods selected CHF patients diagnosed according to the heart function classification standard of New York heart disease association in the United States, according to the living sea. 2260 M group CHF patients were extracted, 67 cases in the healthy control group and 3300 M group CHF, 62 in the control group. The plasma adiponectin, chemokine, leptin level, mean ventricular wall stress (mean wall stress, MWS) and ventricular mass index (left ventricular mass index) were calculated. Adiponectin, chemokine, leptin level and MWS, LVMI were higher than 2260 m groups (P0.01); adiponectin, chemokine, leptin level and MWS, LVMI were higher in the same altitude CHF than in healthy controls; MWS and LVMI were positively correlated with adiponectin, chemokine and leptin levels (P0.01). These changes are involved in the pathophysiology of CHF development.
【作者单位】：青海大学研究生院临床医学系;青海省人民医院干部保健科;
【基金】：青海省科技计划项目(2013-T-Y30)~~
【分类号】：R541.61

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