巴马小型猪冠状动脉粥样硬化模型中炎症因子和病理形态学分析

发布时间：2018-08-09 16:28

【摘要】：目的:观察巴马小型猪冠状动脉粥样硬化模型血清炎症因子变化,探讨炎症与冠状动脉粥样硬化发病的关系,同时观察冠脉的病理改变。方法:将巴马小型猪随机分配,对照组予基础饲料喂饲,模型组予高脂喂饲联合球囊拉伤。在多个时间点分别对两组行血管内超声、血清炎症因子检测和病理学分析。结果:第24周,冠状动脉血管内超声示对照组平均面积狭窄率为6.56%,模型组平均面积狭窄率为44.12%。第24周、28周、36周和48周,模型组hs-CRP、IL-6、VCAM-1、MCP-1和s P-selectin明显高于同期对照组,统计学差异显著。模型组24周可见冠状动脉内膜局部不规则增厚,增厚的内膜中存在泡沫细胞;48周可见冠状动脉内膜不规则增厚,粥样斑块形成,增厚的内膜中存在大量脂质、泡沫细胞、炎细胞及增生的纤维组织,动脉中膜受压变薄。结论:炎症反应在AS发生、发展和恶化中起重要作用,炎症加速了斑块的进展。
[Abstract]:Aim: to observe the changes of serum inflammatory factors and the relationship between inflammation and coronary atherosclerosis, and to observe the pathological changes of coronary artery in Bama miniature pig coronary atherosclerosis model. Methods: Bama miniature pigs were randomly assigned, the control group was fed with basic feed, and the model group was fed with high fat feeding combined with balloon strain. Intravascular ultrasound, serum inflammatory factor detection and pathological analysis were performed at multiple time points. Results: at the 24th week, the mean area stenosis rate was 6.56 in the control group and 44.12 in the model group. The MCP-1 and s P-selectin of hs-CRP IL-6 VCAM-1 in the model group were significantly higher than those in the control group (P < 0.05). In the model group, irregular thickening of coronary intima was observed at 24 weeks, foam cells were found in thickened intima, irregular thickening of intima and formation of atherosclerotic plaque were observed in the thickened intima of coronary artery at 48 weeks, and a large number of lipids and foam cells were found in thickened intima. Inflammatory cells and proliferating fibrous tissue, the media of the artery are thinned under pressure. Conclusion: inflammation plays an important role in the occurrence, development and deterioration of as, and inflammation accelerates the progression of plaque.
【作者单位】：辽宁中医药大学;辽宁中医药大学附属医院血脉病研究室;
【基金】：国家重点基础研究发展计划(2013CB531704)
【分类号】：R-332;R541.4

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