替格瑞洛片治疗复杂冠心病的临床研究

发布时间：2018-08-13 20:10

【摘要】：目的观察替格瑞洛片治疗复杂冠心病的临床疗效和安全性。方法将125例复杂冠心病患者随机分为对照组63例和试验组62例。对照组予以氢氯吡格雷,术前每次300 mg,术后每次75 mg,qd,口服;试验组予以替格瑞洛,术前每次180 mg,术后90 mg,qd,口服。2组患者均治疗1年。比较2组患者的临床疗效、心功能,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为87.10%(54例/62例)和71.43%(45例/63例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的肌酸激酶同工酶分别为(16.37±2.01)和(59.73±10.62)μg·L-1,肌红蛋白分别为(42.08±11.86)和(123.28±50.63)μg·L-1,肌钙蛋白T分别为(0.01±0.01)和(0.06±0.03)μg·L-1,B型脑钠肽分别为(44.44±3.11)和(68.62±10.37)ng·L-1,左心室射血分数分别为(57.22±1.61)%和(25.36±5.38)%,差异均有统计学意义(均P0.05)。2组患者药物不良反应主要有出血、呼吸困难、心律失常。试验组和对照组的总药物不良反应发生率分别为24.19%和31.75%,差异无统计学意义(P0.05)。结论替格瑞洛片治疗复杂冠心病的临床疗效确切,其能显著提高患者的心功能,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of tigrello tablets in the treatment of complex coronary heart disease. Methods 125 patients with complicated coronary heart disease were randomly divided into control group (63 cases) and experimental group (62 cases). The control group was given hydroclopidogrel 300 mg / time before operation and 75 mg / g QD after operation, while the test group was given tigrilol 180 mg before operation and 90 mg / d after operation. All the patients in group 2 were treated for 1 year. The clinical efficacy, cardiac function and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 87.10% (54 / 62) and 71.43% (45 / 63), respectively. The difference was statistically significant (P0.05). After treatment, The levels of creatine kinase isoenzyme (16.37 卤2.01) and (59.73 卤10.62) 渭 g L -1, myoglobin (42.08 卤11.86) and (123.28 卤50.63) 渭 g L -1, troponin T were (0.01 卤0.01) and (0.06 卤0.03) 渭 g / L ~ (-1) ng / L ~ (-1), respectively. The left ventricular ejection fraction (LVEF) was (57.22 卤1.61)% and (25.36 卤5.38), respectively. The main adverse drug reactions in group 2 (P0.05) were bleeding. Dyspnea, arrhythmia. The incidence of total adverse drug reactions in the test group and control group were 24.19% and 31.75%, respectively, with no significant difference (P0.05). Conclusion tigrello tablet is effective in the treatment of complex coronary heart disease. It can significantly improve the cardiac function of the patients and does not increase the incidence of adverse drug reactions.
【作者单位】：河南省胸科医院心血管九病区;郑州大学第一附属医院心血管内科;
【基金】：河南省科技攻关基金资助项目(201403235)
【分类号】：R541.4

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