宁夏农村居民血清脂联素和hs-CRP水平与高血压前期关系研究

发布时间：2018-08-14 12:18

【摘要】：目的分析高血压前期人群中血清脂联素和超敏C-反应蛋白(hypersensitive C-reactive protein,hsCRP)水平与心血管危险因素的关系,探讨血清脂联素和hs-CRP对高血压前期的影响。方法在宁夏地区2008-2012年开展的横断面研究的基础上,将血压值按诊断标准分为正常组、高血压前期组和高血压组,收集人体测量数据和采集血液进行血清脂联素和hs-CRP水平的测定。结果血清脂联素水平随着血压的升高呈递减趋势(Z=41.798,P0.001),hs-CRP呈递增趋势(Z=31.213,P0.001)。偏相关分析显示在调整年龄、性别、民族、文化程度、吸烟、饮酒和体育锻炼后,高血压前期人群中血清脂联素分别与体质指数(body mass index,BMI)、腰围、腰臀比、空腹血糖、胰岛素抵抗指数、舒张压、总胆固醇和甘油三酯呈负相关,与高密度脂蛋白胆固醇呈正相关(均有P0.05);血清hs-CRP分别与BMI、腰围、腰臀比、空腹血糖、收缩压和甘油三酯呈正相关(均有P0.05)。Logistics回归分析显示,血清脂联素水平高是高血压前期的保护因素(OR=0.462,95%CI:0.263~0.811,P=0.007),血清hs-CRP与高血压前期的发生并无统计学关联(均有P0.05)。结论高血压前期已出现血清脂联素和hs-CRP水平的变化,并且与心血管危险因素间相互影响,同时血清脂联素是高血压前期的保护因素。
[Abstract]:Objective to analyze the relationship between serum adiponectin and hypersensitive C-reactive hsCRP levels and cardiovascular risk factors in prehypertensive population, and to explore the effect of serum adiponectin and hs-CRP on prehypertension. Methods based on the cross-sectional study conducted in Ningxia from 2008 to 2012, the blood pressure was divided into normal group, prehypertension group and hypertension group according to the diagnostic criteria. The anthropometric data were collected and blood samples were collected for the determination of serum adiponectin and hs-CRP levels. Results the serum adiponectin level decreased with the increase of blood pressure (P 0.001) and the level of hs-CRP increased with the increase of blood pressure (P 0.001). Partial correlation analysis showed that after adjusting for age, sex, nationality, education, smoking, alcohol consumption and physical exercise, serum adiponectin and body mass index (body mass), waist circumference, waist-to-hip ratio, fasting blood glucose were measured, respectively. Insulin resistance index, diastolic blood pressure, total cholesterol and triglyceride were negatively correlated with high density lipoprotein cholesterol (all P 0.05), serum hs-CRP was correlated with BMI, waist circumference, waist-to-hip ratio, fasting blood glucose, respectively. There was a positive correlation between systolic blood pressure (SBP) and triglyceride (P0.05). Logistics regression analysis showed that high serum adiponectin level was the protective factor of prehypertension (ORO 0.462C95 CI: 0. 263: 0. 811P0. 007). There was no significant correlation between serum hs-CRP and prehypertension (P0.05). Conclusion the changes of serum adiponectin and hs-CRP levels have occurred in prehypertensive patients, and they are related to cardiovascular risk factors, and serum adiponectin is the protective factor of prehypertension.
【作者单位】：宁夏医科大学公共卫生与管理学院流行病与卫生统计学系;
【基金】：国家自然科学基金(81160358)
【分类号】：R544.1

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