平均血小板体积对急性ST段抬高型心肌梗死患者预后的影响
发布时间：2018-08-17 12:57
【摘要】：目的:评价平均血小板体积(MPV)对急性ST段抬高型心肌梗死(STEMI)患者预后的影响。方法:连续入选2010-01-01至2014-10-31于我院住院确诊为STEMI并接受经皮冠状动脉介入治疗(PCI)的1 012例患者,于2015-10进行随访,记录主要不良心血管事件(MACE)。基于受试者工作特征(ROC)曲线确定的全因死亡的MPV最佳界值,将患者分为低MPV组和高MPV组。比较两组患者MACE发生率,并用单因素及多因素COX回归分析MPV对接受PCI治疗的STEMI患者预后的影响。结果:ROC曲线确定的全因死亡的MPV最佳界值为9.466 fl,低MPV组549例(MPV≤9.466 fl)和高MPV组463例(MPV9.466 fl)。随访时间为34(12~69)个月。与低MPV组比,高MPV组患者PCI后具有更高的全因死亡(P0.001)及心原性死亡发生率(P=0.001)。多因素校正后,COX回归分析仍显示入院高MPV为接受PCI的STEMI患者全因死亡(HR=1.463,P0.001)及心原性死亡(HR=1.458,P0.001)事件的独立危险因素。结论:入院MPV增高对PCI后STEMI患者的长期预后有预测价值。
[Abstract]:Objective: to evaluate the effect of mean platelet volume (MPV) on the prognosis of patients with acute St segment elevation myocardial infarction (St segment elevation myocardial infarction) (STEMI). Methods: a total of 1,012 consecutive patients who were admitted to our hospital from 2010-01-01 to 2014-10-31 to receive percutaneous coronary intervention (PCI) were enrolled and followed up in 2015-10 to record major adverse cardiovascular events (MACE). Patients were divided into two groups: low MPV group and high MPV group based on the optimal MPV threshold of all-cause death determined by operating characteristic (ROC) curve. The incidence of MACE was compared between the two groups, and the influence of univariate and multivariate COX regression analysis (MPV) on the prognosis of STEMI patients treated with PCI was analyzed. Results the optimal limit of MPV for all-cause death was 9.466 fll, 549cases in low MPV group (MPV 鈮，
本文编号：2187703
[Abstract]:Objective: to evaluate the effect of mean platelet volume (MPV) on the prognosis of patients with acute St segment elevation myocardial infarction (St segment elevation myocardial infarction) (STEMI). Methods: a total of 1,012 consecutive patients who were admitted to our hospital from 2010-01-01 to 2014-10-31 to receive percutaneous coronary intervention (PCI) were enrolled and followed up in 2015-10 to record major adverse cardiovascular events (MACE). Patients were divided into two groups: low MPV group and high MPV group based on the optimal MPV threshold of all-cause death determined by operating characteristic (ROC) curve. The incidence of MACE was compared between the two groups, and the influence of univariate and multivariate COX regression analysis (MPV) on the prognosis of STEMI patients treated with PCI was analyzed. Results the optimal limit of MPV for all-cause death was 9.466 fll, 549cases in low MPV group (MPV 鈮，
本文编号：2187703
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