高血压前期患者升主动脉可扩张性特征及危险因素研究

发布时间：2018-08-20 18:04

【摘要】：目的:探讨高血压前期患者的升主动脉可扩张性特征及其危险因素。方法:入选我院接受回顾性心电门控冠状动脉计算机断层摄影术(CT)成像检查的健康体检或临床怀疑冠心病的所有患者。共206例纳入研究,其中理想血压组85例和高血压前期组121例。采用128层双源CT。将原始数据每间隔5%RR间期进行全时相重建。以垂直于左冠状动脉主干发出主动脉根部层面为参考平面,取其上25 mm作为感兴趣层面。计算升主动脉可扩张性。结果:高血压前期组升主动脉可扩张性明显小于理想血压组(P0.01)。高血压前期组升主动脉标化Ss较理想血压组增大,但差异无统计学意义(P0.05)。升主动脉可扩张性在性别、高血脂与血脂正常之间均无差异。相关性分析显示升主动脉可扩张性与年龄(r=-0.69,P=0.001)、收缩压(r=-0.37,P=0.001)、脉压(r=-0.43,P=0.001)和糖化血红蛋白(r=-0.43,P0.05)之间呈负相关。年龄(标化β=-0.66,P=0.001)和收缩压(标化β=-0.44,P=0.001)是升主动脉可扩张性减退的独立影响因子。结论:在不增加造影剂用量和辐射剂量的前提下,利用回顾性心电门控冠状动脉CT成像早期检测高血压前期人群升主动脉可扩张性变化及其危险因素,有助于识别危险性较高的个体。
[Abstract]:Objective: to investigate the characteristics and risk factors of ascending aorta dilatation in prehypertensive patients. Methods: all the patients with suspected coronary heart disease were enrolled in our hospital who underwent retrospective electrocardiogram gated coronary artery computed tomography (CT). A total of 206 cases were included in the study, including 85 cases of ideal blood pressure group and 121 cases of prehypertension group. Adopt 128 layer dual source CTs. The original data were reconstructed on a full-time basis with 5%RR intervals. The aortic root plane perpendicular to the left main coronary artery was taken as the reference plane and the upper 25 mm was taken as the interested plane. The distensibility of ascending aorta was calculated. Results: the dilatability of ascending aorta in prehypertension group was significantly lower than that in ideal blood pressure group (P0.01). The Ss of ascending aorta in pre-hypertension group was larger than that in ideal blood pressure group, but the difference was not statistically significant (P0.05). There was no significant difference in the expansibility of ascending aorta between sex, hyperlipidemia and normal blood lipids. Correlation analysis showed that distensibility of ascending aorta was negatively correlated with age (r = -0.69), systolic pressure (r = 0.37), pulse pressure (n = 0.43) and glycosylated hemoglobin (P 0.05). Age (standardized 尾 -0.66U P0. 001) and systolic blood pressure (SBP) were independent influencing factors of ascending aorta dilatability. Conclusion: without increasing the dosage of contrast media and radiation dose, retrospective ECG gated coronary artery CT imaging was used to detect the dilatability of ascending aorta and its risk factors. Help to identify individuals with higher risk.
【作者单位】：兖矿集团总医院放射科;海军旅顺红营子干休所;大连医科大学附属第一医院心脏CT检查科;
【分类号】：R544.1;R816.2

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