原发性高血压患者血清25-羟基维生素D水平与血压变异性的相关性研究
发布时间：2018-08-21 13:31
【摘要】：目的：探讨原发性高血压患者血清25-羟基维生素D[25(OH)D]水平与血压变异性(BPV)的相关性,为高血压的临床治疗提供依据。方法：连续性选取2012年6—12月在新疆医科大学第一附属医院住院部就诊的原发性高血压患者140例,所有患者行24 h动态血压监测并测定血清25(OH)D水平,根据血清25(OH)D水平分为25(OH)D非缺乏组65例和25(OH)D缺乏组75例,比较两组患者的血压水平和BPV,并分析25(OH)D与BPV之间的关系。结果：25(OH)D缺乏组的诊室收缩压(cSBP)、诊室舒张压(cDBP)、24 h收缩压(24hSBP)、24 h舒张压(24 hDBP)、日间收缩压(dSBP)、日间舒张压(dDBP)、夜间收缩压(nSBP)、夜间舒张压(nDBP)、24h收缩压标准差(24 hSSD)、24 h舒张压标准差(24 hDSD)、日间收缩压标准差(dSSD)、日间舒张压标准差(dDSD)、夜间收缩压标准差(nSSD)、夜间舒张压标准差(nDSD)均高于25(OH)D非缺乏组,差异均有统计学意义(P0.05)。血清25(OH)D水平与24 hSSD、24 hDSD、dSSD、dDSD呈负相关(r值分别为-0.483、-0.320、-0.437、-0.301,P0.01)。多元线性回归分析显示,25(OH)D对24 hSSD的影响有统计学意义(P0.01)。结论：原发性高血压患者25(OH)D的缺乏可引起BPV的增加。
[Abstract]:Objective: to investigate the correlation between serum 25 hydroxyvitamin D [25 (OH) D] and blood pressure variability (BPV) in patients with essential hypertension. Methods: one hundred and forty patients with essential hypertension who were hospitalized in the first affiliated Hospital of Xinjiang Medical University from June to December 2012 were selected. All patients were monitored for 24 h ambulatory blood pressure (ABBP) and the serum 25 (OH) D level was measured. According to the serum 25 (OH) D level, 65 cases of 25 (OH) D non-deficiency group and 75 cases of 25 (OH) D deficiency group were divided into two groups. The blood pressure and BPV were compared between the two groups, and the relationship between 25 (OH) D and BPV was analyzed. Results diastolic blood pressure (cDBP) in (cSBP), room was 24 h systolic blood pressure (24hSBP) 24 h diastolic blood pressure (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD) (dDBP), night systolic blood pressure (nSBP), night diastolic blood pressure (nDBP) (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD). (24 hDSD), daytime systolic blood pressure standard deviation (dSSD), daytime diastolic pressure standard deviation (dDSD), nocturnal systolic pressure standard deviation (nSSD), night diastolic blood pressure standard deviation (nDSD) were higher than 25 (OH) D group; The difference was statistically significant (P0.05). There was a negative correlation between the serum 25 (OH) D level and the 24 hour SDD DSDN dDSD (r values were -0.483U -0.3207U -0.437U -0.301g P0.01, respectively). Multiple linear regression analysis showed that the effect of 25 (OH) D on 24 hSSD was statistically significant (P0.01). Conclusion: the lack of 25 (OH) D in patients with essential hypertension can induce the increase of BPV.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.11
本文编号：2195887
[Abstract]:Objective: to investigate the correlation between serum 25 hydroxyvitamin D [25 (OH) D] and blood pressure variability (BPV) in patients with essential hypertension. Methods: one hundred and forty patients with essential hypertension who were hospitalized in the first affiliated Hospital of Xinjiang Medical University from June to December 2012 were selected. All patients were monitored for 24 h ambulatory blood pressure (ABBP) and the serum 25 (OH) D level was measured. According to the serum 25 (OH) D level, 65 cases of 25 (OH) D non-deficiency group and 75 cases of 25 (OH) D deficiency group were divided into two groups. The blood pressure and BPV were compared between the two groups, and the relationship between 25 (OH) D and BPV was analyzed. Results diastolic blood pressure (cDBP) in (cSBP), room was 24 h systolic blood pressure (24hSBP) 24 h diastolic blood pressure (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD) (dDBP), night systolic blood pressure (nSBP), night diastolic blood pressure (nDBP) (24 hSSD) 24 h diastolic blood pressure standard deviation (24 hSSD). (24 hDSD), daytime systolic blood pressure standard deviation (dSSD), daytime diastolic pressure standard deviation (dDSD), nocturnal systolic pressure standard deviation (nSSD), night diastolic blood pressure standard deviation (nDSD) were higher than 25 (OH) D group; The difference was statistically significant (P0.05). There was a negative correlation between the serum 25 (OH) D level and the 24 hour SDD DSDN dDSD (r values were -0.483U -0.3207U -0.437U -0.301g P0.01, respectively). Multiple linear regression analysis showed that the effect of 25 (OH) D on 24 hSSD was statistically significant (P0.01). Conclusion: the lack of 25 (OH) D in patients with essential hypertension can induce the increase of BPV.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.11
【参考文献】
相关期刊论文 前1条
1 李世云;李勤;李强;郑振;熊萍;苟晓琴;钱少平;;成都市成人维生素D营养状况[J];中国骨质疏松杂志;2012年11期
，本文编号：2195887
本文链接：https://www.wllwen.com/yixuelunwen/xxg/2195887.html
最近更新
教材专著
