控制不同INR对老年稳定性冠心病合并房颤患者的临床观察

发布时间：2018-08-27 18:37

【摘要】：目的观察老年稳定性冠心病合并非瓣膜性心房颤动患者在使用华法林抗凝治疗过程中控制不同血浆凝血酶原时间国际标准化比值(INR)的预后和安全性影响。方法选择老年稳定性冠心病合并非瓣膜性心房颤动患者81例,随机分为A组(低抗凝组)41例,调整INR 1.5~2.0;B组(常规抗凝组)40例,调整INR 2.0~3.0。随访时间为1年,比较两组主要终点事件及安全性终点情况。结果治疗1年后,比较两组INR和华法林的剂量,A组显著低于B组,差异具有统计学意义(P0.01);治疗结束时两组终点事件比较,差异无统计学意义(P0.05);两组患者都没有致命性出血事件发生,出血事件比例B组高于A组,差异具有统计学意义(P0.01)。结论华法林低强度抗凝可预防老年稳定性冠心病合半非瓣膜性心房颤动患者缺血性脑卒中等血栓事件发生。
[Abstract]:Objective to investigate the prognostic and safety effects of different plasma prothrombin time ratios (INR) in elderly patients with stable coronary heart disease (CHD) complicated with non-valvular atrial fibrillation (NAF) during warfarin anticoagulant therapy. Methods Eighty-one elderly patients with stable coronary heart disease complicated with non-valvular atrial fibrillation were randomly divided into three groups: group A (low anticoagulant group, n = 41), group B (conventional anticoagulant group, n = 40, adjusted INR 1.5 + 2.0) and INR 2.0, 3.0, respectively. The follow-up time was 1 year to compare the main endpoint events and safety endpoints between the two groups. Results after one year of treatment, the dose of INR and warfarin in group A was significantly lower than that in group B (P0.01). There was no significant difference between the two groups (P0.05). There were no fatal bleeding events in the two groups. The proportion of bleeding events in group B was higher than that in group A. the difference was statistically significant (P0.01). Conclusion warfarin low-intensity anticoagulation can prevent ischemic stroke in elderly patients with stable coronary heart disease and semi-non-valvular atrial fibrillation.
【作者单位】：重庆三峡医药高等专科学校附属医院心内科;
【分类号】：R541.4;R541.75

【相似文献】