强化剂量阿托伐他汀对不稳定型心绞痛患者PCI围手术期B7-H3、B7-H4的影响

发布时间：2018-09-08 07:54

【摘要】：目的探讨强化剂量阿托伐他汀对不稳定型心绞痛患者经皮冠状动脉介入治疗(PCI)围手术期B7-H3和B7-H4表达的影响。方法将80例不稳定型心绞痛患者随机分为常规剂量组(阿托伐他汀20 mg/d,n=40)和强化剂量组(阿托伐他汀80 mg/d,n=40),分别于PCI术前和术后18~24 h收集外周静脉血,采用ELISA检测外周血白细胞介素4(IL-4)、白细胞介素10(IL-10)、干扰素γ(IFN-γ)、血清可溶性B7-H3(sB7-H3)、可溶性B7-H4(sB7-H4)水平,用实时荧光定量PCR检测外周血单核细胞B7-H3、B7-H4 mRNA相对表达量。结果两组患者PCI术后IL-10、sB7-H3、sB7-H4水平和B7-H3、B7-H4的mRNA表达水平均较术前升高,其中强化剂量组升高更显著(P0.05)。相反,两组患者PCI术后IL-4、IFN-γ水平均降低,且强化剂量组较常规剂量组下降更明显(P0.05)。结论强化剂量阿托伐他汀可能通过促进B7-H3、B7-H4表达,从而降低不稳定型心绞痛患者PCI术后免疫炎症反应。
[Abstract]:Objective to investigate the effect of enhanced dose of Atto vastatin on the expression of B7-H3 and B7-H4 in patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI) in perioperative period of (PCI). Methods 80 patients with unstable angina pectoris were randomly divided into routine dose group (Atto vastatin 20 mg/d,n=40) and enhanced dose group (Atto vastatin 80 mg/d,n=40). Peripheral venous blood was collected before and after PCI at 1824 hours. The levels of interleukin-4 (IL-4), interleukin-10 (IL-10), interferon 纬 (IFN- 纬), serum soluble B7-H3 (sB7-H3) and soluble B7-H4 (sB7-H4) were detected by ELISA. The relative expression of B7-H3OB7-H4 mRNA in peripheral blood monocytes was detected by real-time fluorescence quantitative PCR. Results the levels of IL-10,sB7-H3,sB7-H4 and mRNA expression of B7-H _ 3 and B _ 7-H _ 4 after PCI in both groups were higher than those before operation, especially in the enhanced dose group (P0.05). On the contrary, the level of IL-4,IFN- 纬 decreased in both groups after PCI, and the level of IL-4,IFN- 纬 in the enhanced dose group was significantly lower than that in the conventional dose group (P0.05). Conclusion the enhanced dose of Atto vastatin may decrease the immune inflammation after PCI in patients with unstable angina pectoris by promoting the expression of B7-H _ 3 and B _ 7-H _ 4.
【作者单位】：广西医科大学第一附属医院心血管内科;广西中医药大学第一附属医院中西医结合心血管内科;玉林市红十字会医院心血管内科;益阳医学高等专科学校附属医院内一科;永州市中心医院心血管内科;
【基金】：广西科学研究与技术开发计划项目(科技攻关1355005-4-6)
【分类号】：R541.4

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