血清半乳糖凝集素-3及炎症因子与冠脉病变程度和主要心脏不良事件的相关性
发布时间：2018-09-10 08:16
【摘要】：目的观察冠心病患者血清半乳糖凝集素-3(Galectin-3,Gal-3)及炎症因子超敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)水平变化,探讨冠心病患者血清Gal-3、Hs-CRP、IL-6、TNF-a与冠脉病变程度及30天内主要心脏不良事件(MACE)的相关性。方法选取我院心内科一病区住院患者180例作为研究对象,根据冠脉造影结果分为冠心病组(n=126例)和对照组(n=54例),检测所有入选患者血清Gal-3、Hs-CRP、IL-6、TNF-a的水平。在冠心病组中根据不同血管病变支数分为单支病变组(n=54例)、双支病变组(n=40例)和多支病变组(n=32例);再根据冠状动脉狭窄的严重程度分为轻度狭窄组(n=51例)和重度狭窄组(n=75例);根据Gensini评分系统对所有研究对象进行评分,并对冠心病患者出院后进行为期30天的电话或门诊随访,记录每一位冠心病患者30天内MACE的发生情况(主要包括心绞痛、心肌梗死、心力衰竭及心源性死亡等),并据此分为MACE组(n=23例)和无MACE组(n=104例)。分析各组间血清Gal-3、Hs-CRP、IL-6、TNF-a水平变化,同时从冠脉不同病变血管支数、冠脉狭窄程度和Gensini评分三方面来探讨血清Gal-3、Hs-CRP、IL-6、TNF-a的水平与冠脉病变程度的关系,并分析其与及MACE之间的相关性。结果1.冠心病组血清Gal-3、Hs-CRP、IL-6、TNF-a水平及Gensini评分显著高于对照组(P0.01)。2.冠状动脉多支病变组血清Gal-3、Hs-CRP、IL-6、TNF-a水平显著高于双支、单支病变组及对照组(P0.05);双支病变组又明显高于单支病变组及对照组(P0.05)。3.冠状动脉重度狭窄组血清Gal-3、Hs-CRP、IL-6、TNF-a水平显著高于轻度狭窄组和对照组(P0.01);而轻度狭窄组又明显高于对照组(P0.05)。4.冠心病组血清Gal-3、Hs-CRP、IL-6、TNF-a水平与Gensini积分呈正相关(回归系数r=0.639、0.553、0.267、0.211,P0.01,P0.05)。5.对冠心病组进行30天电话或门诊随访,结果显示MACE组中的Gal-3、Hs-CRP、IL-6、TNF-a水平显著高于无MACE组(P0.01,P0.05)。结论1.冠心病患者血清Gal-3及Hs-CRP、IL-6、TNF-a水平明显升高,并与冠状动脉病变程度密切相关,提示血清Gal-3可用来初步评估冠状动脉病变的严重程度。2.冠心病患者血清Gal-3及Hs-CRP、IL-6、TNF-a水平与30天MACE密切相关,提示Gal-3可作为冠心病患者近期预后的新观察指标。
[Abstract]:Objective to observe the changes of serum galactose agglutinin 3 (Galectin-3,Gal-3), inflammatory factor hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in patients with coronary heart disease (CHD). To investigate the correlation between serum Gal-3,Hs-CRP,IL-6,TNF-a and severity of coronary artery disease and (MACE) of main adverse cardiac events in 30 days in patients with coronary heart disease. Methods 180 inpatients in one ward of cardiology in our hospital were divided into coronary heart disease group (n = 126) and control group (n = 54) according to the results of coronary angiography. The serum Gal-3,Hs-CRP,IL-6,TNF-a levels of all patients were measured. In coronary heart disease group, 54 patients were divided into single vessel disease group (n = 54), double vessel lesion group (n = 40) and multivessel disease group (n = 32), and then divided into mild stenosis group (n = 51) and severe coronary artery stenosis group (n = 51) according to the severity of coronary artery stenosis. In the stenosis group (n = 75), all subjects were evaluated according to the Gensini scoring system. Patients with coronary heart disease were followed up by telephone or outpatient for 30 days after discharge. The incidence of MACE in each patient was recorded (including angina pectoris, myocardial infarction, angina pectoris, myocardial infarction). Heart failure and cardiac death were divided into MACE group (n = 23) and no MACE group (n = 104). The changes of serum Gal-3,Hs-CRP,IL-6,TNF-a levels were analyzed. The relationship between serum Gal-3,Hs-CRP,IL-6,TNF-a level and coronary lesion degree was discussed from three aspects: the number of coronary artery branches, the degree of coronary stenosis and the Gensini score, and the correlation between Gal-3,Hs-CRP,IL-6,TNF-a and MACE was also analyzed. Result 1. The serum Gal-3,Hs-CRP,IL-6,TNF-a level and Gensini score in CHD group were significantly higher than those in control group (P0.01). The level of serum Gal-3,Hs-CRP,IL-6,TNF-a in multi-vessel coronary artery lesion group was significantly higher than that in double vessel group, single vessel lesion group and control group (P0.05), and double vessel lesion group was significantly higher than single vessel lesion group and control group (P0.05). 3. The serum Gal-3,Hs-CRP,IL-6,TNF-a level in severe coronary stenosis group was significantly higher than that in mild stenosis group and control group (P0.01), while that in mild stenosis group was significantly higher than that in control group (P0.05). 4. There was a positive correlation between serum Gal-3,Hs-CRP,IL-6,TNF-a level and Gensini score in coronary heart disease group (regression coefficient r = 0.639U 0.553U 0.267U 0.211P 0.01P 0.05) .5. The results showed that the level of Gal-3,Hs-CRP,IL-6,TNF-a in MACE group was significantly higher than that in no MACE group (P 0.05). Conclusion 1. The levels of serum Gal-3 and Hs-CRP,IL-6,TNF-a were significantly increased in patients with coronary heart disease, and were closely related to the severity of coronary artery disease, suggesting that serum Gal-3 could be used to evaluate the severity of coronary artery disease. The levels of serum Gal-3 and Hs-CRP,IL-6,TNF-a in patients with coronary heart disease were closely correlated with MACE at 30 days, suggesting that Gal-3 could be used as a new index of short-term prognosis in patients with coronary heart disease.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4
本文编号：2233882
[Abstract]:Objective to observe the changes of serum galactose agglutinin 3 (Galectin-3,Gal-3), inflammatory factor hypersensitive C-reactive protein (Hs-CRP), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) in patients with coronary heart disease (CHD). To investigate the correlation between serum Gal-3,Hs-CRP,IL-6,TNF-a and severity of coronary artery disease and (MACE) of main adverse cardiac events in 30 days in patients with coronary heart disease. Methods 180 inpatients in one ward of cardiology in our hospital were divided into coronary heart disease group (n = 126) and control group (n = 54) according to the results of coronary angiography. The serum Gal-3,Hs-CRP,IL-6,TNF-a levels of all patients were measured. In coronary heart disease group, 54 patients were divided into single vessel disease group (n = 54), double vessel lesion group (n = 40) and multivessel disease group (n = 32), and then divided into mild stenosis group (n = 51) and severe coronary artery stenosis group (n = 51) according to the severity of coronary artery stenosis. In the stenosis group (n = 75), all subjects were evaluated according to the Gensini scoring system. Patients with coronary heart disease were followed up by telephone or outpatient for 30 days after discharge. The incidence of MACE in each patient was recorded (including angina pectoris, myocardial infarction, angina pectoris, myocardial infarction). Heart failure and cardiac death were divided into MACE group (n = 23) and no MACE group (n = 104). The changes of serum Gal-3,Hs-CRP,IL-6,TNF-a levels were analyzed. The relationship between serum Gal-3,Hs-CRP,IL-6,TNF-a level and coronary lesion degree was discussed from three aspects: the number of coronary artery branches, the degree of coronary stenosis and the Gensini score, and the correlation between Gal-3,Hs-CRP,IL-6,TNF-a and MACE was also analyzed. Result 1. The serum Gal-3,Hs-CRP,IL-6,TNF-a level and Gensini score in CHD group were significantly higher than those in control group (P0.01). The level of serum Gal-3,Hs-CRP,IL-6,TNF-a in multi-vessel coronary artery lesion group was significantly higher than that in double vessel group, single vessel lesion group and control group (P0.05), and double vessel lesion group was significantly higher than single vessel lesion group and control group (P0.05). 3. The serum Gal-3,Hs-CRP,IL-6,TNF-a level in severe coronary stenosis group was significantly higher than that in mild stenosis group and control group (P0.01), while that in mild stenosis group was significantly higher than that in control group (P0.05). 4. There was a positive correlation between serum Gal-3,Hs-CRP,IL-6,TNF-a level and Gensini score in coronary heart disease group (regression coefficient r = 0.639U 0.553U 0.267U 0.211P 0.01P 0.05) .5. The results showed that the level of Gal-3,Hs-CRP,IL-6,TNF-a in MACE group was significantly higher than that in no MACE group (P 0.05). Conclusion 1. The levels of serum Gal-3 and Hs-CRP,IL-6,TNF-a were significantly increased in patients with coronary heart disease, and were closely related to the severity of coronary artery disease, suggesting that serum Gal-3 could be used to evaluate the severity of coronary artery disease. The levels of serum Gal-3 and Hs-CRP,IL-6,TNF-a in patients with coronary heart disease were closely correlated with MACE at 30 days, suggesting that Gal-3 could be used as a new index of short-term prognosis in patients with coronary heart disease.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R541.4
【参考文献】
相关期刊论文 前6条
1 陈伟伟;高润霖;刘力生;朱曼璐;王文;王拥军;吴兆苏;李惠君;顾东风;杨跃进;郑哲;蒋立新;胡盛寿;;《中国心血管病报告2015》概要[J];中国循环杂志;2016年06期
2 陈伟伟;高润霖;刘力生;朱曼璐;王文;王拥军;吴兆苏;李惠君;郑哲;蒋立新;胡盛寿;;《中国心血管病报告2014》概要[J];中国循环杂志;2015年07期
3 李徽;姚炯涛;张少利;;冠心病患者血清Gal-3检测的临床价值分析[J];河北医药;2015年10期
4 秦月;仲琳;杨军;;冠心病患者冠状动脉病变程度与半乳糖凝集素-3水平的相关性分析[J];中国循环杂志;2015年05期
5 张育民;李庆宽;全勇;史桂霞;肖晓霞;李峰;陈科新;梁薇芬;;急性心肌梗死患者血清半乳糖凝集素3水平与冠状动脉病变的相关性[J];中国动脉硬化杂志;2014年06期
6 孙利强;陈杰;李恩;刘宗芳;张丽华;简立国;;急性冠脉综合征患者血清半乳糖凝集素-3和C反应蛋白水平的变化[J];郑州大学学报(医学版);2014年03期
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