心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床研究

发布时间：2018-09-13 08:59

【摘要】：目的观察心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床疗效及安全性。方法将99例慢性心力衰竭老年患者随机分为对照组46例和试验组53例。对照组予以运动康复训练;试验组在对照组治疗的基础上,予以心舒宁胶囊每次2.0~3.2 g,tid,口服。2组患者均治疗8周。比较2组患者的临床疗效、心功能指标,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为90.57%(48例/53例)和71.74%(33例/46例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的左心室收缩末期内径分别为(31.94±4.68)和(38.85±4.01)mm,左心室舒张末期内径分别为(47.21±7.81)和(54.58±7.75)mm,左心室心肌重量指数分别为(58.84±4.73)和(52.37±5.01)g·m~(-2),左心室射血分数分别为(49.91±6.95)%和(44.23±5.29)%,左心房内径分别为(34.34±6.27)和(40.32±6.52)mm,差异均有统计学意义(均P0.05)。2组患者发生的药物不良反应以头痛、胃肠道反应、皮疹为主,且试验组和对照组的药物不良反应发生率分别为5.66%和10.87%,差异无统计学意义(P0.05)。结论心舒宁胶囊联合康复训练治疗老年慢性心力衰竭的临床疗效显著,其能显著改善患者的心功能,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of Xinshuning capsule combined with rehabilitation training in the treatment of senile chronic heart failure. Methods 99 elderly patients with chronic heart failure were randomly divided into control group (n = 46) and trial group (n = 53). The control group was given exercise rehabilitation training, and the experimental group was treated with Xinshuning capsule for 8 weeks on the basis of the treatment of the control group. The clinical efficacy, cardiac function index and adverse drug reaction were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 90.57% (48 / 53) and 71.74% (33 / 46), respectively. The difference was statistically significant (P0.05). After treatment, The left ventricular end-systolic diameter of the trial group and the control group were (31.94 卤4.68) and (38.85 卤4.01) mm, respectively (47.21 卤7.81) and (54.58 卤7.75) mm,. The left ventricular mass index was (58.84 卤4.73) and (52.37 卤5.01) g m-2, and the left ventricular ejection fraction was (49.91 卤6.95)% and (44.23 卤5.29), respectively. (34.34 卤6.27) and (40.32 卤6.52) mm, respectively (P0.05). The incidence of adverse drug reactions in the experimental group and the control group was 5.66% and 10.87 respectively with no significant difference (P0.05). Conclusion Xinshuning capsule combined with rehabilitation training is effective in the treatment of elderly patients with chronic heart failure. It can significantly improve the heart function of the patients and does not increase the incidence of adverse drug reactions.
【作者单位】：辽宁医药职业学院康复教研室;辽宁中医药大学第一临床学院心内科;河北医科大学第二医院心内科;
【基金】：河北省科学研究重点课题计划基金资助项目(ZL20140073)
【分类号】：R541.6

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