优质L-天冬酰胺酶的开发与应用及重组表达研究进展
发布时间：2018-09-17 17:25
【摘要】：L-天冬酰胺酶用于治疗急性淋巴细胞白血病与淋巴瘤,但高昂的价格限制了临床上的广泛应用,重组表达解决了成本的难题。L-天冬酰胺酶所具有的低谷氨酰胺酶活性是其副作用的根源,同时细菌来源的L-天冬酰胺酶能导致危及生命的过敏反应,寻找副作用更低的优质L-天冬酰胺酶及其修饰方法,成为研究的重点。对L-天冬酰胺酶的重组表达,及具有更优性质的L-天冬酰胺酶开发进展进行了综述,并阐明其在临床治疗及食品工业领域的巨大应用潜力。
[Abstract]:L- asparaginase is used in the treatment of acute lymphoblastic leukemia and lymphoma, but the high price limits the wide range of clinical applications. Recombinant expression solves the cost problem. The low activity of L-asparaginase is the root cause of its side effects, and the bacterial-derived L-asparaginase can lead to life-threatening allergic reactions. It has become the focus of research to search for high quality L-asparaginase with lower side effects and its modification methods. The recombinant expression of L- asparaginase and the development progress of L- asparaginase with better properties were reviewed, and the great application potential of L- asparaginase in the field of clinical treatment and food industry was expounded.
【作者单位】： 江苏恒瑞医药股份有限公司国家靶向药物工程技术研究中心;
【分类号】：Q78;R733
[Abstract]:L- asparaginase is used in the treatment of acute lymphoblastic leukemia and lymphoma, but the high price limits the wide range of clinical applications. Recombinant expression solves the cost problem. The low activity of L-asparaginase is the root cause of its side effects, and the bacterial-derived L-asparaginase can lead to life-threatening allergic reactions. It has become the focus of research to search for high quality L-asparaginase with lower side effects and its modification methods. The recombinant expression of L- asparaginase and the development progress of L- asparaginase with better properties were reviewed, and the great application potential of L- asparaginase in the field of clinical treatment and food industry was expounded.
【作者单位】： 江苏恒瑞医药股份有限公司国家靶向药物工程技术研究中心;
【分类号】：Q78;R733
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