肾功能、体重指数等因素对血浆氨基末端脑钠肽前体水平的影响

发布时间：2018-10-09 10:31

【摘要】：目的探讨肾功能、体重指数(BMI)等因素对血浆氨基末端脑钠肽前体(NT-proBNP)水平的影响。方法选择慢性心力衰竭(CHF)患者140例,非CHF患者88例。测量患者的NT-proBNP水平、估测的肾小球滤过率(e GFR)及BMI。通过单因素及多因素相关分析,探讨e GFR、BMI、性别、年龄、左房内径(LAD)、左心室射血分数(LVEF)、NYHA心功能分级及心房颤动(AF)等因素对NT-proBNP水平的影响。结果 (1)单因素相关分析显示,e GFR和BMI均与NT-proBNP水平负相关(r=-0.249,P=0.000 1;r=-0.157,P=0.018),多因素分析亦显示e GFR和BMI与NT-proBNP水平独立相关(P0.01)。(2)自变量包含e GFR的多因素分析显示年龄与NT-proBNP水平并不独立相关(P0.10),而未对e GFR进行校正的多因素分析显示年龄是NT-proBNP水平的独立影响因素(P=0.006)。(3)多元回归分析显示,LAD、LVEF、NYHA心功能分级及AF是NT-proBNP水平的独立影响因素(P0.005),而性别对NT-proBNP水平无影响(P0.10)。结论血浆NT-proBNP水平受肾功能、BMI的影响,肾功能减退是老年患者NT-proBNP水平升高的主要机制之一。
[Abstract]:Objective to investigate the effects of renal function and body mass index (BMI) on plasma amino-terminal brain natriuretic peptide precursor (NT-proBNP) levels. Methods 140 patients with (CHF) and 88 patients with non-CHF were selected. NT-proBNP level was measured and glomerular filtration rate (e GFR) and BMI. were estimated. By univariate and multivariate correlation analysis, the effects of sex, age, left atrial diameter, left ventricular ejection fraction (LVEF) and left ventricular ejection fraction (LVEF) on NT-proBNP were investigated. Results (1) univariate correlation analysis showed that both e GFR and BMI were negatively correlated with NT-proBNP level (r = 0.249). Multivariate analysis also showed that e GFR and BMI were independently correlated with NT-proBNP level (P0.01). (2). Multivariate analysis showed that age was correlated with NT-proBNP level. Multiple regression analysis showed that age was an independent factor of NT-proBNP level (P0. 006). (3). Multiple regression analysis showed that LVEF NYHA grade and AF were independent factors of NT-proBNP level (P0. 005), but gender had no effect on NT-proBNP level (P0. 10). Conclusion Plasma NT-proBNP level is affected by renal function. Renal dysfunction is one of the main mechanisms of increasing NT-proBNP level in elderly patients.
【作者单位】：河南大学淮河医院心内科;
【分类号】：R541.6

【相似文献】