青海地区藏、汉族H型高血压患者CIMT、FMD、血浆Hcy分析

发布时间：2018-10-11 06:57

【摘要】：目的:探讨青海地区藏、汉族H型高血压患者颈动脉内中膜厚度(CIMT)、血管内皮功能(FMD)、血浆同型半胱氨酸(Hcy)间的相互关系,通过比较所采集的藏、汉族H型高血压患者CIMT、FMD和Hcy水平,用统计学方法来比较相对应指标之间是否具有差异性及其相关性。方法:收集高血压病人共计131人,汉族85人,藏族46人。所入选病例均行颈动脉超声检查,测定CIMT值即在颈总动脉分叉处近端lcm测量CIMT值3次的平均值作为最终记录值。采用高分辨力超声检测血管内皮功能的方法,检测FMD。测定血浆Hcy水平时采用循环酶的方法(由同一人检测)。结果:(1)本次收集各组病例的年龄、病史、BPM、DPM、TC、TG、LDL、HDL均无统计学差异。(2)不同型高血压患者,汉族不同类型高血压CIMT、FMD、血浆Hcy均有统计学差异(P0.05),其中CIMT及血浆Hcy平均值汉族H型高血压组高于非H型高血压组,FMD平均值前者低于后者;藏族不同类型高血压FMD、血浆Hcy比较有统计学差异,H型高血压组血浆Hcy平均水平高于非H型高血压组,FMD平均值前者平均值低于后者;藏、汉族非H高血压组比较,FMD比较有统计学差异(P0.05),并且前者平均值低于后者平均值;藏、汉族H型高血压组比较,血浆Hcy有统计学差异(P0.05),前者平均值高于后者。(3)汉族非H型高血压患者CIMT、FMD、血浆Hcy与可能相关因素无相关。(4)藏、汉族H型高血压CIMT跟年龄、血浆Hcy呈正相关;与FMD呈负相关;与病史无相关;FMD与血浆Hcy、CIMT呈负相关,与病史均无相关,汉族H型高血压FMD和年龄呈负相关;血浆Hcy与FMD呈负相关,与CIMT呈正相关,与年龄无相关。(5)藏族非H型高血压患者CIMT和病史、FMD、血浆Hcy相关,与其它指标均无相关。结论:(1)青海地区藏汉族H型高血压患者间CIMT、FMD未见民族不同,但在血浆Hcy水平上存在民族差异性;(2)藏、汉族H型高血压患者血浆Hcy和FMD、CIMT存在相关性,在FMD方面的相关因素中存在不同。
[Abstract]:Objective: to investigate the relationship between carotid intima-media thickness (CIMT),) endothelial function (FMD),) and plasma homocysteine (Hcy) (Hcy) in patients with H type hypertension in Qinghai and Han nationality, and to compare the CIMT,FMD and Hcy levels in patients with H type hypertension. The statistical method was used to compare the difference and correlation between the corresponding indicators. Methods: a total of 131 patients with hypertension were collected, 85 of Han nationality and 46 of Tibetan nationality. All the patients were examined by carotid ultrasound. The CIMT value was measured by lcm at the proximal end of the common carotid artery as the final recorded value. High resolution ultrasound was used to detect vascular endothelial function and FMD. was detected. The level of plasma Hcy was measured by circulating enzyme method (detected by the same person). Results: (1) there was no significant difference in age, history and BPM,DPM,TC,TG,LDL,HDL among the three groups. (2) there was no significant difference in age, history and BPM,DPM,TC,TG,LDL,HDL among the patients with different types of hypertension. There were significant differences in plasma Hcy between different types of hypertension in Han nationality (P0.05). The mean value of CIMT and plasma Hcy in H type hypertension group was higher than that in non H type hypertension group, and FMD average value in the former group was lower than that in the latter group. The average level of plasma Hcy in H type hypertension group was higher than that in non H type hypertension group, and the FMD average value in the former was lower than that in the latter group. There was significant difference in FMD between Han nationality and non-H hypertension group (P0.05), and the average value of the former was lower than that of the latter, while that of Tibetan and Han patients with H type hypertension was lower than that of the latter. There was significant difference in plasma Hcy (P0.05), the former was higher than that of the latter. (3) there was no correlation between plasma Hcy and possible related factors in Han non-H hypertension patients. (4) in Han nationality, CIMT of H type hypertension was positively correlated with age, plasma Hcy was positively correlated with FMD, and negatively correlated with FMD. There was no correlation between FMD and history, no correlation between FMD and plasma Hcy,CIMT, and negative correlation between FMD and age in patients with H type hypertension in Han nationality, and there was a positive correlation between plasma Hcy and FMD and CIMT. There was no correlation between age and age. (5) there was no correlation between CIMT, history, FMD, plasma Hcy and other indexes in Tibetan patients with non-H hypertension. Conclusion: (1) there is no difference in CIMT,FMD between H type hypertension patients of Tibetan and Han nationality in Qinghai area, but there is a national difference in plasma Hcy level, (2) there is a correlation between plasma Hcy and FMD,CIMT in Tibetan and Han nationality patients with H type hypertension. There are differences in FMD related factors.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1

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