冠心病合并特殊临床情况的相关研究
发布时间:2018-10-12 16:38
【摘要】:目的分析急性心肌梗死(acute myocardial infarction, AMI)合并急性肺栓塞(acute pulmonary embolism, APE)的临床参数和长期随访结果,讨论该病发生的危险因素,评价抗栓药物的疗效及患者预后。方法回顾性分析2004年3月至2014年5月在阜外医院确诊的AMI合并APE的34例患者的临床参数,对其进行电话随访,并行Kaplan-Meier分析。结果本组患者年龄≥60岁、高血压、糖尿病、高脂血症、冠心病史、长期卧床的比例较高,临床表现以胸闷、呼吸困难、胸痛、大汗为主,临床体征以肺部湿罗音为主,主要通过肺动脉CT增强扫描确诊。阿司匹林+氯吡格雷+华法林(三联抗栓)组出血率较高,但均为非致命性山血,无血栓事件发生,与其他组相比相对安全、有效。患者总死亡率为20.6%,较AMI或APE高。结论AMI合并APE临床情况复杂,临床预后差,胸闷、胸痛、呼吸困难、大汗症状突出,主要通过肺动脉CT增强扫描明确诊断,三联抗栓治疗是相对安全有效的。目的评价75岁及以.上老年患者在经皮冠状动脉介入治疗(PCI)术后远期预后是否存在性别差异。方法连续入选2004-04至2010-11期间在我院行PCI的29 211例冠心病患者,分为:≥75岁女性组(521例)、75岁女性组(5 666例)、≥75岁男性组(1 098例)和75岁男性组(21 926例)。比较各组患者PCI术后住院期和远期预后。结果住院期间,≥75岁女性组心原性死亡发生率明显高于其他三组。Kaplan-Meier生存分析显示≥75岁女性3年心原性死亡的发生率明显高于其他三组患者(P0.05)。COX比例风险模型分析显示:与75岁女性及75岁男性比,≥75岁女性是心原性死亡(HR=2.53,95%CI:1.15~5.59:HR=2.22,95%CI:1.26-3.91)和心原性死亡/心肌梗死(HR=2.26,95%CI:1.27~4.03:HR=2.25,95% CI:1.44-3.51)的独立危险因素。但与≥75岁男性相比,≥75岁女性不是心原性死亡(HR=1.30,95%CI:0.97~1.71)和心原性死亡/心肌梗死(HR=1.21,957 %CI:0.94-1.55)的独立危险因素。结论与其他人群相比,75岁及以上老年女性PCI术后住院期和远期预后较差,但其不是PCI术后预后不佳的独立危险因素。
[Abstract]:Objective to analyze the clinical parameters and long-term follow-up results of acute myocardial infarction (acute myocardial infarction, AMI) complicated with acute pulmonary embolism (acute pulmonary embolism, APE), to discuss the risk factors of the disease, and to evaluate the efficacy and prognosis of antithrombotic drugs. Methods the clinical parameters of 34 patients with AMI combined with APE diagnosed in Fuwei Hospital from March 2004 to May 2014 were analyzed retrospectively. The patients were followed up by telephone and analyzed by Kaplan-Meier. Results the age 鈮,
本文编号:2266842
[Abstract]:Objective to analyze the clinical parameters and long-term follow-up results of acute myocardial infarction (acute myocardial infarction, AMI) complicated with acute pulmonary embolism (acute pulmonary embolism, APE), to discuss the risk factors of the disease, and to evaluate the efficacy and prognosis of antithrombotic drugs. Methods the clinical parameters of 34 patients with AMI combined with APE diagnosed in Fuwei Hospital from March 2004 to May 2014 were analyzed retrospectively. The patients were followed up by telephone and analyzed by Kaplan-Meier. Results the age 鈮,
本文编号:2266842
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