ACEI制剂与高血压合并腔隙性脑梗死患者脑血管反应性的相关性研究

发布时间：2018-10-13 10:04

【摘要】：目的探讨长效血管紧张素转换酶抑制剂(ACEI)对高血压合并腔隙性脑梗死(LI)患者脑血管反应性(CVR)的影响。方法将该院2015年1月至2016年1月收治的67例高血压病合并LI患者分为观察组(35例)与对照组(32例),在基础治疗的基础上,观察组口服贝那普利,对照组口服左旋氨氯地平,比较两组患者CVR的改善状况。结果治疗前两组患者平均动脉压(BP)水平和屏气指数(BHI)比较,差异均无统计学意义(P0.05);治疗后,观察组患者BP为(91.05±6.82)mm Hg低于对照组的(98.68±9.67)mm Hg,BHI[左侧:1.51±0.41;右侧:1.49±0.38]高于对照组[左侧:1.32±0.34;右侧:1.28±0.31],差异均有统计学意义(P0.05)。结论长效ACEI治疗高血压合并LI,能改善患者的CVR,不仅有助于控制患者血压,改善LI症状,还能控制病情进展,预防卒中发生。
[Abstract]:Objective to investigate the effect of long acting angiotensin converting enzyme inhibitor (ACEI) on cerebrovascular reactive (CVR) in hypertensive patients with lacunar cerebral infarction (LI). Methods from January 2015 to January 2016, 67 patients with hypertension complicated with LI were divided into observation group (n = 35) and control group (n = 32). On the basis of basic treatment, benazepril was administered orally in the observation group and levamlodipine was taken orally in the control group. The improvement of CVR was compared between the two groups. Results there was no significant difference in mean arterial pressure (BP) level and breath-holding index (BHI) between the two groups before treatment (P0.05). The BP of the patients in the observation group was (91.05 卤6.82) mm Hg lower than that in the control group (98.68 卤9.67) mm Hg,BHI [left: 1.51 卤0.41; right: 1.49 卤0.38], which was significantly higher than that in the control group [left: 1.32 卤0.34; right: 1.28 卤0.31] (P0.05). Conclusion Long-term ACEI can not only help to control the blood pressure, improve the symptoms of LI, but also control the progression of the disease and prevent the occurrence of stroke in patients with hypertension combined with LI,.
【作者单位】：河北医科大学第三医院神经内科;
【基金】：河北省医学科学研究重点课题项目(20110411)
【分类号】：R544.1;R743.3

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