酒石酸美托洛尔及心率对高血压病患者中心动脉收缩压的影响
发布时间：2018-10-13 18:06
【摘要】：目的:1.探讨β受体阻滞剂酒石酸美托洛尔对高血压病患者和正常血压者中心动脉收缩压的影响;2.探讨不同用药方案及不同心率水平对高血压病患者中心动脉收缩压的影响。方法:1、入选受试者86例(高血压病患者46例,正常血压者40例),测量肱动脉压、心率、中心动脉压,服用酒石酸美托洛尔25mg,30分钟后再次测量,比较分析用药前后各数据改变;2、根据患者用药情况,将患者分为不同单用药组及不同联合用药组,分别比较各组间心率、中心动脉收缩压及肱动脉收缩压与中心动脉收缩压差值;3、根据心率情况将入选的371例受试者平均分为四组,分别比较各组间中心动脉收缩压及肱动脉收缩压与中心动脉收缩压差值。结果:1.口服酒石酸美托洛尔30分钟后,高血压病患者心率、肱动脉收缩压、中心动脉收缩压均有下降,但肱动脉收缩压与中心动脉收缩压差值减小(9.55±4.47比7.60±3.85 mm Hg,P0.05);正常血压者有相同的趋势。2.钙离子通道阻滞剂组、肾素-血管紧张素系统抑制剂组、β受体阻滞剂组三组间心率、肱动脉收缩压与中心动脉收缩压差值差异无统计学意义(HR:74.39±10.70、72.95±10.41和71.08±8.90次/分,P0.05;SBP-CASP:9.21±5.58、10.29±4.19和8.38±3.59mm Hg,P0.05);含β受体阻滞剂的联合用药组和不含β受体阻滞剂的联合用药组间心率、肱动脉收缩压与中心动脉收缩压差值差异无统计学意义(HR:71.45±11.19比71.56±9.66次/分,P0.05;SBP-CASP:8.92±4.66比8.97±3.05mm Hg,P0.05)。3.心率≤64次/分、65-72次/分、73-80次/分、≥81次/分四组间肱动脉收缩压与中心动脉收缩压差值分别为7.07±2.97 mm Hg、6.94±3.05 mm Hg、8.74±3.40 mm Hg和11.94±5.40mm Hg,在≤64次/分及65-72次/分组间肱动脉收缩压与中心动脉收缩压差值差异无统计学意义,余各组间差异有统计学意义。4.肱动脉收缩压与中心动脉收缩压差值与心率及身高有关,心率每下降1次/分,肱动脉收缩压与中心动脉收缩压差值减少0.176mm Hg;身高每增加1cm,肱动脉收缩压与中心动脉收缩压差值增加0.184mm Hg。结论:1.口服酒石酸美托洛尔能快速降低高血压病患者的外周肱动脉血压、心率和中心动脉压,但随着心率下降,肱动脉收缩压与中心动脉收缩压之间差值减小。2.影响肱动脉收缩压与中心动脉收缩压差值的是心率,而不是药物本身,当心率≤72次/分时,肱动脉收缩压与中心动脉收缩压差值较小且趋于稳定。
[Abstract]:Objective: 1. To investigate the effect of 尾 -blocker metoprolol tartrate on systolic blood pressure of central artery in patients with hypertension and normal blood pressure. To investigate the effects of different drug regimen and heart rate on systolic blood pressure of central artery in patients with hypertension. Methods: 1. The brachial artery pressure, heart rate, central artery pressure were measured in 86 subjects (46 patients with hypertension and 40 patients with normal blood pressure). After taking metoprolol tartrate for 30 minutes, the blood pressure of brachial artery was measured again. 2, according to the drug use, the patients were divided into two groups: single drug group and different combination group, and the heart rate was compared among each group. The systolic blood pressure of the central artery and the difference between the systolic blood pressure of the brachial artery and the systolic blood pressure of the central artery. 3. According to the heart rate, 371 subjects were divided into four groups on average. The systolic blood pressure of the central artery and the difference between the systolic blood pressure of the brachial artery and the central artery were compared. The result is 1: 1. After oral administration of metoprolol tartrate for 30 minutes, the heart rate, systolic blood pressure of brachial artery and systolic pressure of central artery were all decreased in patients with hypertension. However, the difference between the systolic blood pressure of brachial artery and that of central artery was decreased (9.55 卤4.47 vs 7.60 卤3.85 mm Hg,P0.05). The heart rate of calcium channel blocker group, renin-angiotensin system inhibitor group and 尾 receptor blocker group were compared. There was no significant difference between the systolic blood pressure of brachial artery and that of central artery (HR:74.39 卤10.70 卤72.95 卤10.41 and 71.08 卤8.90 beats / min, P0.05 卤SBP-CASP: 9.21 卤5.58 卤10.29 卤4.19 and 8.38 卤3.59mm Hg,P0.05). There was no significant difference between the systolic blood pressure of brachial artery and the systolic blood pressure of central artery (HR:71.45 卤11.19 vs 71.56 卤9.66 beats / min, P 0.05 SBP-CASP: 8.92 卤4.66 vs 8.97 卤3.05mm Hg,P0.05). Heart rate 鈮，
本文编号：2269480
[Abstract]:Objective: 1. To investigate the effect of 尾 -blocker metoprolol tartrate on systolic blood pressure of central artery in patients with hypertension and normal blood pressure. To investigate the effects of different drug regimen and heart rate on systolic blood pressure of central artery in patients with hypertension. Methods: 1. The brachial artery pressure, heart rate, central artery pressure were measured in 86 subjects (46 patients with hypertension and 40 patients with normal blood pressure). After taking metoprolol tartrate for 30 minutes, the blood pressure of brachial artery was measured again. 2, according to the drug use, the patients were divided into two groups: single drug group and different combination group, and the heart rate was compared among each group. The systolic blood pressure of the central artery and the difference between the systolic blood pressure of the brachial artery and the systolic blood pressure of the central artery. 3. According to the heart rate, 371 subjects were divided into four groups on average. The systolic blood pressure of the central artery and the difference between the systolic blood pressure of the brachial artery and the central artery were compared. The result is 1: 1. After oral administration of metoprolol tartrate for 30 minutes, the heart rate, systolic blood pressure of brachial artery and systolic pressure of central artery were all decreased in patients with hypertension. However, the difference between the systolic blood pressure of brachial artery and that of central artery was decreased (9.55 卤4.47 vs 7.60 卤3.85 mm Hg,P0.05). The heart rate of calcium channel blocker group, renin-angiotensin system inhibitor group and 尾 receptor blocker group were compared. There was no significant difference between the systolic blood pressure of brachial artery and that of central artery (HR:74.39 卤10.70 卤72.95 卤10.41 and 71.08 卤8.90 beats / min, P0.05 卤SBP-CASP: 9.21 卤5.58 卤10.29 卤4.19 and 8.38 卤3.59mm Hg,P0.05). There was no significant difference between the systolic blood pressure of brachial artery and the systolic blood pressure of central artery (HR:71.45 卤11.19 vs 71.56 卤9.66 beats / min, P 0.05 SBP-CASP: 8.92 卤4.66 vs 8.97 卤3.05mm Hg,P0.05). Heart rate 鈮，
本文编号：2269480
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