老年高血压患者外周血内脂素水平变化与氧化应激及促炎因子的关系

发布时间：2018-10-17 12:15

【摘要】：目的分析老年高血压患者外周血内脂素水平变化与氧化应激的促炎因子的关系。方法老年高血压患者40例为观察组,老年健康体检者50例为对照组。检测并对比两组外周血内脂素、炎症因子及氧化应激指标。结果观察组内脂素水平显著高于对照组(P0.01),观察组血清白细胞介素(IL)-6水平显著高于对照组(P0.01)。观察组C反应蛋白(CRP)水平显著高于对照组,且超氧化物歧化酶(SOD)水平显著低于对照组(P0.01)。相关性分析显示,观察组外周血内脂素水平与IL-6(r=0.630,P0.01)及CRP(r=0.883,P0.01)呈正相关,与SOD(r=-0.872,P0.01)呈负相关。结论老年高血压患者外周血内脂素水平显著升高,且与氧化应激及促炎因子水平密切相关,具有一定临床检测价值。
[Abstract]:Objective to analyze the relationship between lipid level in peripheral blood and oxidative stress proinflammatory factor in elderly patients with hypertension. Methods 40 elderly patients with hypertension were treated as observation group and 50 elderly healthy persons as control group. The levels of lipid, inflammatory factors and oxidative stress in peripheral blood of the two groups were detected and compared. Results the level of lipid in the observation group was significantly higher than that in the control group (P0. 01), and the serum interleukin (IL)-6 level in the observation group was significantly higher than that in the control group (P0. 01). The levels of C-reactive protein (CRP) and superoxide dismutase (SOD) in the observation group were significantly higher than those in the control group (P0.01). The correlation analysis showed that the level of lipid in peripheral blood of the observation group was positively correlated with IL-6 (r ~ 0.630) and CRP (r ~ (0.883) P _ (0.01), and negatively with SOD (r ~ (-0.872) P _ (0.01). Conclusion the level of lipid in peripheral blood of elderly patients with hypertension is significantly increased, and is closely related to the levels of oxidative stress and pro-inflammatory factor, which has a certain clinical value.
【作者单位】：沧州医学高等专科学校;沧州市中心医院心电检查科;
【基金】：沧州医学高等专科学校2014年院级课题(No.141302126)
【分类号】：R544.1

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