青年与老年尸体颈总动脉流变特性对比分析

发布时间：2018-10-18 19:00

【摘要】：背景:研究发现,随着年龄增加和血压的增高,血管基质退化使弹力层断裂和破碎,使钙质和胶原沉积,大动脉和主动脉扩张导致动脉僵硬度的提高。目的:对比分析青年颈总动脉组和老年颈总动脉的流变特性,为研究颈总动脉粥样硬化的发病机制提供流变特性基础。方法:随机取青年尸体和老年尸体颈总动脉组各10个试样,分别进行应力松弛、蠕变实验,随机取青年和老年颈总动脉组1个试样进行组织形态观察。结果与结论:(1)青年颈总动脉组试样7 200 s应力下降量显著大于老年颈总动脉组(P0.05);(2)青年颈总动脉组试7 200 s应变上升量显著大于老年颈总动脉组(P0.05);(3)扫描电镜观察发现,老年颈总动脉组可见脂质斑块,泡沫细胞积聚,内弹力层和中弹力板发生变性、断裂和崩解,内膜和中膜可见大量的斑快和炎细胞浸润,组织形态具有动脉粥样硬化的特征;青年颈总动脉组未见粥样硬化斑块;(4)结果说明,随着年龄的增加,老年颈总动脉弹性纤维和胶原纤维的排列关系被打乱,其应力松弛、蠕变特性发生了改变。
[Abstract]:Background: with the increase of age and blood pressure, the degeneration of vascular matrix leads to the breaking and breaking of elastic layer, the deposition of calcium and collagen, and the increase of arterial stiffness due to dilatation of aorta and aorta. Objective: to compare and analyze the rheological characteristics of common carotid artery in young and old people, and to provide a basis for studying the pathogenesis of common carotid artery atherosclerosis. Methods: ten specimens of common carotid artery of young cadavers and 10 specimens of common carotid artery of old cadavers were randomly selected for stress relaxation and creep test. Results and conclusion: (1) the stress decrease of 7 200s in the young common carotid artery group was significantly higher than that in the elderly common carotid artery group (P0.05); (2), and the increase of the strain at 7 200 s in the young common carotid artery group was significantly higher than that in the elderly common carotid artery group (P0.05); (3). In the elderly common carotid artery group, lipid plaque, foam cell accumulation, degeneration, rupture and disintegration of the inner elastic layer and the elastic plate were observed. A large number of plaque and inflammatory cells were found in the intima and media, and the tissue morphology was characterized by atherosclerosis. (4) the results showed that the arrangement of elastic fibers and collagen fibers in the common carotid artery was disturbed with the increase of age, and the stress relaxation and creep characteristics of the common carotid artery were changed.
【作者单位】：吉林大学中日联谊医院神经外科;吉林省人民医院眼科;吉林大学中日联谊医院超声科;
【基金】：吉林省科技发展计划资助项目(20110492)~~
【分类号】：R543.4

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