中年高血压患者阿司匹林抵抗及其相关危险因素分析

发布时间：2018-10-21 12:19

【摘要】：目的探讨中年高血压患者发生阿司匹林抵抗的危险因素。方法应用血栓弹力图测定2012年5月至2015年4月在新乡医学院第三附属医院就诊的中年高血压患者177例,根据是否发生阿司匹林抵抗分为阿司匹林抵抗组和阿司匹林敏感组,比较2组患者的一般临床资料。根据患者血压控制水平分为血压达标组(收缩压140 mm Hg,舒张压90 mm Hg,1 mm Hg=0.133 k Pa)和血压不达标组(收缩压≥140 mm Hg或舒张压≥90 mm Hg),比较2组患者阿司匹林抵抗发生率情况,并对中年高血压患者发生阿司匹林抵抗的危险因素进行logistic回归分析。结果中年高血压患者177例中阿司匹林抵抗发生率为21.5%(38/177)。血压达标组患者阿司匹林抵抗发生率为11.8%(10/85),血压不达标组患者阿司匹林抵抗发生率为30.4%(28/92),血压不达标组患者阿司匹林抵抗发生率显著高于血压达标组(χ~2=8.978,P0.05)。阿司匹林抵抗组患者体质量、空腹血糖均显著高于阿司匹林敏感组(P0.05);阿司匹林抵抗组较阿司匹林敏感组女性比例高(P0.05);logistic回归分析显示,空腹血糖、女性为阿司匹林抵抗的独立危险因素(P0.05)。结论中年高血压患者出现阿司匹林抵抗时,有较多的女性患者,阿司匹林抵抗的发生与患者空腹血糖和血压控制相关。
[Abstract]:Objective to investigate the risk factors of aspirin resistance in middle aged patients with hypertension. Methods from May 2012 to April 2015, 177 middle-aged patients with hypertension were examined by thromboelastography in the third affiliated Hospital of Xinxiang Medical College. According to whether aspirin resistance occurred, 177 patients were divided into aspirin resistance group and aspirin sensitive group. The general clinical data of the two groups were compared. Patients were divided into two groups according to their blood pressure control level (SBP 140 mm Hg, diastolic blood pressure 90 mm Hg,1 mm Hg=0.133 k Pa) and blood pressure substandard group (systolic blood pressure 鈮，

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