冠状动脉粥样硬化性心脏病患者血清补体C3、C4水平与HDL-C的相关性分析
发布时间：2018-10-24 20:45
【摘要】：【目的】研究冠心病人群血清补体C3、C4及高密度脂蛋白胆固醇(HDL-C)水平并分析补体C3、C4与HDL-C在冠心病人群中的相关性。【方法】收集2015年12月至2016年07月于中山大学孙逸仙纪念医院心血管内科住院经冠状动脉造影明确诊断为冠心病的患者共251例,另外收集同期我院博济医疗中心健康体检者214例。冠心病患者分为急性冠脉综合征组180例及稳定性冠心病组71例。各指标采用中山大学孙逸仙纪念医院检验科检验的结果。【结果】(1)急性冠脉综合征组、稳定性冠心病组及健康体检者组的补体C3、C4及HDL-C水平比较,差异具有统计学意义(P0.05)。(2)在急性冠脉综合征及稳定性冠心病组中补体C3、C4与HDL-C无明显相关(P0.05),在健康体检者组中,补体C3与HDL-C成负相关,差异具有统计学意义(均P0.05)。【结论】冠心病患者补体C3、C4水平升高,HDL水平下降,而炎症活动可能影响补体与HDL-C的相关性。
[Abstract]:[objective] to study the levels of complement C _ 3C _ 4 and high density lipoprotein cholesterol (HDL-C) in patients with coronary heart disease and to analyze the correlation between complement C _ 3C _ 4 and HDL-C in coronary heart disease population. [methods] Sun of Sun Yat-sen University from December 2015 to July 2016 was collected. In the Department of Cardiovascular Medicine of Yixian Memorial Hospital, 251 cases of coronary heart disease were diagnosed by coronary angiography. In addition, 214 cases of Boji Medical Center health examination in the same period were collected. Patients with coronary heart disease were divided into acute coronary syndrome group (n = 180) and stable coronary heart disease group (n = 71). The results of laboratory examination of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Sun Yat-sen University were used. [results] (1) the levels of complement C _ 3N _ 4 and HDL-C in patients with acute coronary syndrome, stable coronary heart disease and healthy persons were compared. The difference was statistically significant (P0.05). (2) in acute coronary syndrome and stable coronary heart disease group there was no significant correlation between complement C _ 3C _ 4 and HDL-C (P0.05), in the healthy controls, complement C _ 3 was negatively correlated with HDL-C. The difference was statistically significant (P0.05). [conclusion] the level of complement C _ 3N _ 4 increased and the level of HDL decreased in patients with coronary heart disease, while inflammation may affect the correlation between complement and HDL-C.
【作者单位】： 中山大学孙逸仙纪念医院心内科//广东省心电生理与心律失常重点实验室;茂名市人民医院心内一科;梅州市田家炳医院;
【基金】：国家自然科学基金(81070182) 广东省自然学基金(2014A030313712)
【分类号】：R541.4
，
本文编号：2292510
[Abstract]:[objective] to study the levels of complement C _ 3C _ 4 and high density lipoprotein cholesterol (HDL-C) in patients with coronary heart disease and to analyze the correlation between complement C _ 3C _ 4 and HDL-C in coronary heart disease population. [methods] Sun of Sun Yat-sen University from December 2015 to July 2016 was collected. In the Department of Cardiovascular Medicine of Yixian Memorial Hospital, 251 cases of coronary heart disease were diagnosed by coronary angiography. In addition, 214 cases of Boji Medical Center health examination in the same period were collected. Patients with coronary heart disease were divided into acute coronary syndrome group (n = 180) and stable coronary heart disease group (n = 71). The results of laboratory examination of Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Sun Yat-sen University were used. [results] (1) the levels of complement C _ 3N _ 4 and HDL-C in patients with acute coronary syndrome, stable coronary heart disease and healthy persons were compared. The difference was statistically significant (P0.05). (2) in acute coronary syndrome and stable coronary heart disease group there was no significant correlation between complement C _ 3C _ 4 and HDL-C (P0.05), in the healthy controls, complement C _ 3 was negatively correlated with HDL-C. The difference was statistically significant (P0.05). [conclusion] the level of complement C _ 3N _ 4 increased and the level of HDL decreased in patients with coronary heart disease, while inflammation may affect the correlation between complement and HDL-C.
【作者单位】： 中山大学孙逸仙纪念医院心内科//广东省心电生理与心律失常重点实验室;茂名市人民医院心内一科;梅州市田家炳医院;
【基金】：国家自然科学基金(81070182) 广东省自然学基金(2014A030313712)
【分类号】：R541.4
，
本文编号：2292510
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